Reciprocal regulation of p21 and Chk1 controls the Cyclin D1-RB pathway to mediate senescence onset after G2 arrest
Cellular senescence is an irreversible proliferation withdrawal that can be initiated after DNA damage-induced cell cycle arrest in G2 phase to prevent genomic instability caused by aberrant mitoses. Its onset requires p53 (TP53) and retinoblastoma protein (RB1) family tumour suppressors, but how a temporary cell cycle arrest is converted into a permanent one remains unknown. We show that a … Continue reading Reciprocal regulation of p21 and Chk1 controls the Cyclin D1-RB pathway to mediate senescence onset after G2 arrest