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Home page > Bioinformatics and Modelling > SERANAD Complex Biological Data Analysis Service

SERANAD Complex Biological Data Analysis Service

The Operational Head of the "Complex Biological Data Analysis Service" SERANAD is Thierry Gostan (CNRS IR). The scientific committee of SEARANAD includes Jean-Christophe Andrau, Charles Lecellier, Marc Piechaczyk and Marta Radman-Livaja.

SERANAD mission is to provide bioinformatics support to research projects of IGMM groups in varied domains (genomics, proteomics, imaging, databases generation, etc) and to develop software packages required by these programs.

SERANAD coordinates the acquisition by itself or by research teams of scientific softwares dedictated to the processing of biological data.

SERANAD also proposes internal trainings to personnel members of IGMM on various aspects of bioinformatics and simple and complex statistical analyses through practical exercises showing increasing difficulty.

SERANAD can provide help to IGMM teams by combining mathematics, statistics and programming to conduct the requested analyses and/or novel softwares. Part of its activity relies on a calculation cluster of 256 CPU with 8 nodes and 48Go of RAM, making the limits of the considered methods hardly discernable. Therefore, many developments by SERANAD are linked to the most recent high through-put technologies in genomics, proteomics and imaging.

SERANAD is in close interaction with the Route de Mende mutualized informatic service SI2C2.

For any further information or internships, please contact : thierry.gostan@igmm.cnrs.fr

20 publications linked to the activity SERANAD :

1. Comparison of different extraction techniques to profile microRNAs from human sera and peripheral blood mononuclear cells. Marjorie Monleau, Sophie Bonnel, Thierry Gostan, Dominique Blanchard, Valérie Courgnaud, Charles-Henri Lecellier. BMC genomics. 05/2014; 15(1):395

2. Metabolic and Environmental Conditions Determine Nuclear Genomic Instability in Budding Yeast Lacking Mitochondrial DNA. Léon Dirick, Walid Bendris, Vincent Loubière, Thierry Gostan, Elisabeth Gueydon, Etienne Schwob. Genes Genomes Genetics. 12/2013

3. Characterization and in vivo functional analysis of the Schizosaccharomyces pombe ICLN gene. Adrien Barbarossa, Etienne Antoine, Henry Neel, Thierry Gostan, Johann Soret, Rémy Bordonné. Molecular and Cellular Biology 12/2013

4. Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localization. Florence Rage, Nawal Boulisfane, Khalil Rihan, Henry Neel, Thierry Gostan, Edouard Bertrand, Rémy Bordonné, Johann Soret. RNA 10/2013

5. Lymphotoxin Signaling Is Initiated by the Viral Polymerase in HCV-linked Tumorigenesis. Yannick Simonin, Serena Vegna, Leila Akkari, Damien Grégoire, Etienne Antoine, Jacques Piette, Nicolas Floc’h, Patrice Lassus, Guann-Yi Yu, Arielle R. Rosenberg, Michael Karin, David Durantel, Urszula Hibner. PLoS Pathog. 2013 March; 9(3)

6. Nuclear genome instability in budding yeast lacking mitochondrial DNA depends on environmental parameters. Leon Dirick, Walid Bendris, Vincent Loubiere, Thierry Gostan, Elisabeth Gueydon and Etienne Schwob. (2013)

7. Global profiling of DNA methylation erasure in mouse primordial germ cells. Sylvain Guibert, Thierry Forné, Michael Weber. Genome Res. 2012 April; 22(4)

8. Methylated DNA immunoprecipitation (MeDIP) from low amounts of cells. Borgel J, Guibert S, Weber M. Methods Mol Biol. 2012;925:149-58

9. A novel function for Cyclin A2: Control of cell invasion via RhoA signaling. Nikola Arsic, Nawal Bendris, Marion Peter, Christina Begon-Pescia, Cosette Rebouissou, Gilles Gadéa, Nathalie Bouquier, Frédéric Bibeau, Bénédicte Lemmers, Jean Marie Blanchard. J Cell Biol. 2012 January 9; 196(1)

10. Decreased MCM2-6 in Drosophila S2 Cells Does Not Generate Significant DNA Damage or Cause a Marked Increase in Sensitivity to Replication Interference. Isabelle Crevel, Gilles Crevel, Thierry Gostan, Christelle de Renty, Vincent Coulon, Sue Cotterill. PLoS One. 2011; 6(11)

11. Modulated contact frequencies at gene-rich loci support a statistical helix model for mammalian chromatin organization. Franck Court, Julie Miro, Caroline Braem, Marie-Noëlle Lelay-Taha, Audrey Brisebarre, Florian Atger, Thierry Gostan, Michaël Weber, Guy Cathala, Thierry Forné. Genome Biol. 2011; 12(5)

12. Specific splicing defects in S. pombe carrying a degron allele of the Survival of Motor Neuron gene. Yannick Campion, Henry Neel, Thierry Gostan, Johann Soret, Rémy Bordonné. EMBO J. 2010 June 2; 29(11)

13. Targets and dynamics of promoter DNA methylation during early mouse development. Borgel J, Guibert S, Li Y, Chiba H, Schübeler D, Sasaki H, Forné T, Weber M. Nat Genet. 2010 Dec;42(12)

14. Cohesin organizes chromatin loops at DNA replication factories. Emmanuelle Guillou, Arkaitz Ibarra, Vincent Coulon, Juan Casado-Vela, Daniel Rico, Ignacio Casal, Etienne Schwob, Ana Losada, Juan Méndez. Genes Dev. 2010 December 15; 24(24)

15. ING2 controls the progression of DNA replication forks to maintain genome stability. Delphine Larrieu, Damien Ythier, Romuald Binet, Christian Brambilla, Elisabeth Brambilla, Sagar Sengupta, Rémy Pedeux. EMBO Rep. 2009 October; 10(10)

16. Use of DNA combing for studying DNA replication in vivo in yeast and mammalian cells. Schwob E, de Renty C, Coulon V, Gostan T, Boyer C, Camet-Gabut L, Amato C. Methods Mol Biol. 2009;521:673-87.

17. Simonin, Y., Disson, O., Lerat, H., Antoine, E., Binamé, F., Rosenberg, A. R., Desagher, S., Lassus, P., Bioulac-Sage, P. and Hibner, U. (2009), Calpain activation by hepatitis C virus proteins inhibits the extrinsic apoptotic signaling pathway. Hepatology, 50: 1370–1379.

18. Histone methylation is mechanistically linked to DNA methylation at imprinting control regions in mammals. Henckel A, Nakabayashi K, Sanz LA, Feil R, Hata K, Arnaud P. Hum Mol Genet. 2009 Sep 15;18(18):3375-83.

19. Interplay between S-Cyclin-dependent Kinase and Dbf4-dependent Kinase in Controlling DNA Replication through Phosphorylation of Yeast Mcm4 N-Terminal Domain. Alain Devault, Elisabeth Gueydon, Etienne Schwob. Mol Biol Cell. 2008 May; 19(5)

20. Opposite effects of transforming growth factor-beta activation and rho-associated kinase inhibition on human trophoblast migration in a reconstituted placental-endometrial coculture system. Fafet P, Rebouissou C, Maudelonde T, Vignais ML. Endocrinology. 2008 Sep;149(9):4475-85.


Institut de Génétique Moléculaire de Montpellier
CNRS-UMR 5535 - 1919, Route de Mende - 34293 Montpellier  Cedex 5
FRANCE
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