{"id":2415,"date":"2017-10-23T14:11:16","date_gmt":"2017-10-23T12:11:16","guid":{"rendered":"http:\/\/www.igmm.cnrs.fr\/?page_id=2415"},"modified":"2023-03-16T10:55:29","modified_gmt":"2023-03-16T09:55:29","slug":"agenda","status":"publish","type":"page","link":"https:\/\/www.igmm.cnrs.fr\/en\/agenda\/","title":{"rendered":"AGENDA"},"content":{"rendered":"<h3 style=\"text-align: center;\"><strong><span style=\"color: #d1be00;\">UPCOMING EVENTS<\/span><\/strong><\/h3>\n<p style=\"text-align: center;\">All seminars take place usually each Tuesday at 11 am at 11:00 AM in the meeting room &#8220;Philippe Jeanteur &#8220;.<\/p>\n<div class=\"simcal-calendar simcal-default-calendar simcal-default-calendar-list simcal-default-calendar-light\" data-calendar-id=\"1794\" data-timezone=\"Europe\/Paris\" data-offset=\"7200\" data-week-start=\"1\" data-calendar-start=\"1782856800\" data-calendar-end=\"1804762800\" data-events-first=\"1782981000\" data-events-last=\"1804762800\"><div class=\"simcal-calendar-list \"><nav class=\"simcal-calendar-head\">\n\t<div class=\"simcal-nav\">\n\t\t<button class=\"simcal-nav-button simcal-prev\" title=\"Previous\" aria-label=\"Previous\">\n\t\t\t<i class=\"simcal-icon-left\"><\/i>\n\t\t<\/button>\n\t<\/div>\n\t<div class=\"simcal-nav simcal-current \" data-calendar-current=\"1782856800\">\n\t\t<h3 class=\"simcal-current-label\"> <\/h3>\n\t<\/div>\n\t<div class=\"simcal-nav\">\t\t<button class=\"simcal-nav-button simcal-next\" title=\"Next\" aria-label=\"Next\">\t\t\t<i class=\"simcal-icon-right\"><\/i>\n\t\t<\/button>\n\t<\/div>\n<\/nav>\n<dl class=\"simcal-events-list-container\" data-prev=\"1780264800\" data-next=\"1785535200\" data-heading-small=\"Jul 2026\" data-heading-large=\"July 2026\">\t<dt class=\"simcal-day-label\" style=\"border-bottom: 1px solid #000000;\" ><span style=\"background-color: #000000; color: #ffffff;\"><span class=\"simcal-date-format\" data-date-format=\"j F Y\">2 July 2026<\/span> <\/span><\/dt>\n<dd class=\"simcal-weekday-4 simcal-past simcal-day simcal-day-has-events simcal-day-has-1-events simcal-events-calendar-1794 simcal-day-has-events simcal-day-has-2-events simcal-events-calendar-1794\" data-events-count=\"2\">\n\t<ul class=\"simcal-events\">\n\t<li class=\"simcal-event simcal-event-has-location simcal-events-calendar-1794\" style=\"\" itemscope itemtype=\"http:\/\/schema.org\/Event\" data-start=\"1782981000\">\n\t\t<div class=\"simcal-event-details\"><h4><span class=\"simcal-event-title\" itemprop=\"name\">Robert S. ILLINGWORTH - Institute for Regeneration and Repair, University of Edinburgh<\/span><\/h4>\n<p><em><span class=\"simcal-event-start simcal-event-start-date\" data-event-start=\"1782981000\" data-event-format=\"j F Y\" itemprop=\"startDate\" content=\"2026-07-02T10:30:00+02:00\">2 July 2026<\/span>&nbsp;&nbsp;<span class=\"simcal-event-start simcal-event-start-time\" data-event-start=\"1782981000\" data-event-format=\"G \\h i \\m\\i\\n\" itemprop=\"startDate\" content=\"2026-07-02T10:30:00+02:00\">10 h 30 min<\/span> - <span class=\"simcal-event-end simcal-event-end-time\" data-event-end=\"1782986400\" data-event-format=\"G \\h i \\m\\i\\n\" itemprop=\"endDate\" content=\"2026-07-02T12:00:00+02:00\">12 h 00 min<\/span><\/em><br \/>\n<strong> <span class=\"simcal-event-address simcal-event-start-location\" itemprop=\"location\" itemscope itemtype=\"http:\/\/schema.org\/Place\"><meta itemprop=\"name\" content=\"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France\" \/><meta itemprop=\"address\" content=\"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France\" \/>Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France<\/span><\/strong><\/p>\n<div><div class=\"simcal-event-description\" itemprop=\"description\"><p><span><span><br \/><span><b>Title :<\/b>\u00a0<\/span>Passive Yet Essential, Polycomb Repression in Development and        Disease<\/span><\/span><br \/><b>Contact :<\/b> <a href=\"mailto:carla.heredia@igmm.cnrs.fr\" target=\"_blank\">carla.heredia@igmm.cnrs.fr<\/a><\/p>\n<\/div><\/div>\n<p> <a href=\"https:\/\/www.google.com\/calendar\/event?eid=NTc3MHNjZzFlNmNpbWJsaGJ1NTdwdG5jbG0gZmhmaDgyYnVqZDBjZGJxamc4N2Q3aXU4ajRAZw&#038;ctz=Europe\/Paris\" target=\"_blank\" >Voir plus de d\u00e9tails<\/a><\/p><\/div>\n\t<\/li>\n\t<li class=\"simcal-event simcal-event-has-location simcal-events-calendar-1794\" style=\"\" itemscope itemtype=\"http:\/\/schema.org\/Event\" data-start=\"1782982800\">\n\t\t<div class=\"simcal-event-details\"><h4><span class=\"simcal-event-title\" itemprop=\"name\">Prof. Alan TALEVI (Universidad Nacional de La Plata, La Plata, Argentina)<\/span><\/h4>\n<p><em><span class=\"simcal-event-start simcal-event-start-date\" data-event-start=\"1782982800\" data-event-format=\"j F Y\" itemprop=\"startDate\" content=\"2026-07-02T11:00:00+02:00\">2 July 2026<\/span>&nbsp;&nbsp;<span class=\"simcal-event-start simcal-event-start-time\" data-event-start=\"1782982800\" data-event-format=\"G \\h i \\m\\i\\n\" itemprop=\"startDate\" content=\"2026-07-02T11:00:00+02:00\">11 h 00 min<\/span> - <span class=\"simcal-event-end simcal-event-end-time\" data-event-end=\"1782986400\" data-event-format=\"G \\h i \\m\\i\\n\" itemprop=\"endDate\" content=\"2026-07-02T12:00:00+02:00\">12 h 00 min<\/span><\/em><br \/>\n<strong> <span class=\"simcal-event-address simcal-event-start-location\" itemprop=\"location\" itemscope itemtype=\"http:\/\/schema.org\/Place\"><meta itemprop=\"name\" content=\"Marcel Dor\u00e9e Seminar Room\" \/><meta itemprop=\"address\" content=\"Marcel Dor\u00e9e Seminar Room\" \/>Marcel Dor\u00e9e Seminar Room<\/span><\/strong><\/p>\n<div><div class=\"simcal-event-description\" itemprop=\"description\"><p>CRBM External Seminar<br \/>\n\u201cMachine Learning and Structure-Based Approaches for the Discovery of Biomarkers and Bioactive Compounds\u201d<br \/>\nContact: andrey.kajava@crbm.cnrs.fr<\/p>\n<\/div><\/div>\n<p> <a href=\"https:\/\/www.google.com\/calendar\/event?eid=XzhncDMwZHE2NjEwamNiOWk2OHMzNGI5azhwMmpjYmEyNmtzNDZiOWg4b28zYWRoazg0cGsyY3E2NjQgZmhmaDgyYnVqZDBjZGJxamc4N2Q3aXU4ajRAZw&#038;ctz=Europe\/Paris\" target=\"_blank\" >Voir plus de d\u00e9tails<\/a><\/p><\/div>\n\t<\/li>\n<\/ul>\n\n<\/dd>\n\t<dt class=\"simcal-day-label\" style=\"border-bottom: 1px solid #000000;\" ><span style=\"background-color: #000000; color: #ffffff;\"><span class=\"simcal-date-format\" data-date-format=\"j F Y\">3 July 2026<\/span> <\/span><\/dt>\n<dd class=\"simcal-weekday-5 simcal-past simcal-day simcal-day-has-events simcal-day-has-1-events simcal-events-calendar-1794\" data-events-count=\"1\">\n\t<ul class=\"simcal-events\">\n\t<li class=\"simcal-event simcal-event-has-location simcal-events-calendar-1794\" style=\"\" itemscope itemtype=\"http:\/\/schema.org\/Event\" data-start=\"1783076400\">\n\t\t<div class=\"simcal-event-details\"><h4><span class=\"simcal-event-title\" itemprop=\"name\">Vincent Loubi\u00e8re - IGH Montpellier<\/span><\/h4>\n<p><em><span class=\"simcal-event-start simcal-event-start-date\" data-event-start=\"1783076400\" data-event-format=\"j F Y\" itemprop=\"startDate\" content=\"2026-07-03T13:00:00+02:00\">3 July 2026<\/span>&nbsp;&nbsp;<span class=\"simcal-event-start simcal-event-start-time\" data-event-start=\"1783076400\" data-event-format=\"G \\h i \\m\\i\\n\" itemprop=\"startDate\" content=\"2026-07-03T13:00:00+02:00\">13 h 00 min<\/span> - <span class=\"simcal-event-end simcal-event-end-time\" data-event-end=\"1783080000\" data-event-format=\"G \\h i \\m\\i\\n\" itemprop=\"endDate\" content=\"2026-07-03T14:00:00+02:00\">14 h 00 min<\/span><\/em><br \/>\n<strong> <span class=\"simcal-event-address simcal-event-start-location\" itemprop=\"location\" itemscope itemtype=\"http:\/\/schema.org\/Place\"><meta itemprop=\"name\" content=\"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France\" \/><meta itemprop=\"address\" content=\"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France\" \/>Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France<\/span><\/strong><\/p>\n<div><div class=\"simcal-event-description\" itemprop=\"description\"><p>Title : \u201cEpigenetic            and cis-regulatory determinants of tumorigenesis\"<br \/>\nContact : nadine.laguette@igmm.cnrs.fr<\/p>\n<\/div><\/div>\n<p> <a href=\"https:\/\/www.google.com\/calendar\/event?eid=N2E1bzk4YnUxbjJlZzlkbDJtOGk5bzNrbDMgZmhmaDgyYnVqZDBjZGJxamc4N2Q3aXU4ajRAZw&#038;ctz=Europe\/Paris\" target=\"_blank\" >Voir plus de d\u00e9tails<\/a><\/p><\/div>\n\t<\/li>\n<\/ul>\n\n<\/dd>\n\t<dt class=\"simcal-day-label\" style=\"border-bottom: 1px solid #000000;\" ><span style=\"background-color: #000000; color: #ffffff;\"><span class=\"simcal-date-format\" data-date-format=\"j F Y\">10 July 2026<\/span> <\/span><\/dt>\n<dd class=\"simcal-weekday-5 simcal-past simcal-day simcal-day-has-events simcal-day-has-1-events simcal-events-calendar-1794\" data-events-count=\"1\">\n\t<ul class=\"simcal-events\">\n\t<li class=\"simcal-event simcal-event-has-location simcal-events-calendar-1794\" style=\"\" itemscope itemtype=\"http:\/\/schema.org\/Event\" data-start=\"1783674000\">\n\t\t<div class=\"simcal-event-details\"><h4><span class=\"simcal-event-title\" itemprop=\"name\">Magda CANNATA-SERIO - Institut Curie<\/span><\/h4>\n<p><em><span class=\"simcal-event-start simcal-event-start-date\" data-event-start=\"1783674000\" data-event-format=\"j F Y\" itemprop=\"startDate\" content=\"2026-07-10T11:00:00+02:00\">10 July 2026<\/span>&nbsp;&nbsp;<span class=\"simcal-event-start simcal-event-start-time\" data-event-start=\"1783674000\" data-event-format=\"G \\h i \\m\\i\\n\" itemprop=\"startDate\" content=\"2026-07-10T11:00:00+02:00\">11 h 00 min<\/span> - <span class=\"simcal-event-end simcal-event-end-time\" data-event-end=\"1783679400\" data-event-format=\"G \\h i \\m\\i\\n\" itemprop=\"endDate\" content=\"2026-07-10T12:30:00+02:00\">12 h 30 min<\/span><\/em><br \/>\n<strong> <span class=\"simcal-event-address simcal-event-start-location\" itemprop=\"location\" itemscope itemtype=\"http:\/\/schema.org\/Place\"><meta itemprop=\"name\" content=\"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France\" \/><meta itemprop=\"address\" content=\"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France\" \/>Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France<\/span><\/strong><\/p>\n<div><div class=\"simcal-event-description\" itemprop=\"description\"><p><b>Title:<\/b> \"Signal peptides as timing codes: regulating            protein fate at the ER gate\"<br \/><b>Contact :<\/b> daniel.fisher@igmm.cnrs.fr\u00a0        <\/p>\n<p>The entry of secretory and membrane proteins into the          endoplasmic reticulum (ER) is usually viewed as a rapid          co-translational process driven by N-terminal signal peptides          (SPs). We have uncovered that a subset of SPs can instead          impose a delay at the ER gate, transiently exposing nascent          proteins to the cytosol before their entry into the secretory          pathway. This \u201cdelayed translocation\u201d creates a regulatory          window in which domains normally destined to become          extracellular or luminal can acquire cytosolic modifications.        <br \/>PD-L1 exemplifies this mechanism: its suboptimal SP delays          ER entry and allows cytosolic regulation of its extracellular          domain, shaping PD-L1 maturation, trafficking and function.          Beyond revealing SPs as timing codes, this mechanism exposes          SP-dependent vulnerabilities that can be exploited          pharmacologically. Using two assays we developed, the cytoRUSH          and the RELITE, we show that selective interference with          Sec61-dependent translocation can be monitored and harnessed          to identify small molecules that block PD-L1 ER entry and          redirect it toward cytosolic degradation.        <\/p>\n<p><u><i>References<\/i>\u00a0<\/u>:        <br \/>Cannata Serio, M. et al. A delayed translocation into the          endoplasmic reticulum controls the post-translational          modifications of PD-L1. Nat Commun. 2026 Apr 11; \u00a017(1): 5059.        <\/p>\n<p>Vitale, F. et al. A light-resuming strategy as a screening          method for selecting Sec61 inhibitors down-modulating PD-L1          expression. Nat Commun. 2025 Aug 6; \u00a016(1): 7243.<\/p>\n<\/div><\/div>\n<p> <a href=\"https:\/\/www.google.com\/calendar\/event?eid=M21rZ201ZW1hcGJxdDY3dTZucWk0ZHYwa2ggZmhmaDgyYnVqZDBjZGJxamc4N2Q3aXU4ajRAZw&#038;ctz=Europe\/Paris\" target=\"_blank\" >Voir plus de d\u00e9tails<\/a><\/p><\/div>\n\t<\/li>\n<\/ul>\n\n<\/dd>\n\t<dt class=\"simcal-day-label\" style=\"border-bottom: 1px solid #000000;\" ><span style=\"background-color: #000000; color: #ffffff;\"><span class=\"simcal-date-format\" data-date-format=\"j F Y\">17 July 2026<\/span> <\/span><\/dt>\n<dd class=\"simcal-weekday-5 simcal-past simcal-day simcal-day-has-events simcal-day-has-1-events simcal-events-calendar-1794\" data-events-count=\"1\">\n\t<ul class=\"simcal-events\">\n\t<li class=\"simcal-event simcal-event-has-location simcal-events-calendar-1794\" style=\"\" itemscope itemtype=\"http:\/\/schema.org\/Event\" data-start=\"1784278800\">\n\t\t<div class=\"simcal-event-details\"><h4><span class=\"simcal-event-title\" itemprop=\"name\">Seminar : Alexander Waclawiczek, DKFZ, Heidelberg, Germany<\/span><\/h4>\n<p><em><span class=\"simcal-event-start simcal-event-start-date\" data-event-start=\"1784278800\" data-event-format=\"j F Y\" itemprop=\"startDate\" content=\"2026-07-17T11:00:00+02:00\">17 July 2026<\/span>&nbsp;&nbsp;<span class=\"simcal-event-start simcal-event-start-time\" data-event-start=\"1784278800\" data-event-format=\"G \\h i \\m\\i\\n\" itemprop=\"startDate\" content=\"2026-07-17T11:00:00+02:00\">11 h 00 min<\/span> - <span class=\"simcal-event-end simcal-event-end-time\" data-event-end=\"1784286000\" data-event-format=\"G \\h i \\m\\i\\n\" itemprop=\"endDate\" content=\"2026-07-17T13:00:00+02:00\">13 h 00 min<\/span><\/em><br \/>\n<strong> <span class=\"simcal-event-address simcal-event-start-location\" itemprop=\"location\" itemscope itemtype=\"http:\/\/schema.org\/Place\"><meta itemprop=\"name\" content=\"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France\" \/><meta itemprop=\"address\" content=\"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France\" \/>Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France<\/span><\/strong><\/p>\n<div><div class=\"simcal-event-description\" itemprop=\"description\"><p><b>Title:\u00a0<\/b>The Genotype\u2013Phenotype Relationship as Mediator of Therapy Resistance in Acute Myeloid Leukemia\u00a0<\/p>\n<p><b>Abstract:<\/b><br \/>Acute myeloid leukemia (AML) is characterized by extensive genetic and phenotypic heterogeneity. Leukemic stem cells (LSCs) are a self-renewing subpopulation of AML cells that sustains disease initiation, progression, and relapse. By translating the underlying pathogenic genotype into a malignant cellular phenotype and generating the progeny that constitute the bulk of the leukemia, LSCs lie at the interface between genotype and phenotype. Over the past decade, both genetic alterations and cellular phenotypes have emerged as important determinants of therapeutic response in AML. Deciphering how these features interact within LSCs may therefore provide new insights into treatment response, disease persistence, and the development of therapy resistance.<\/p>\n<p><b>Contact :\u00a0<\/b>guillaume.bossis@igmm.cnrs.fr<\/p>\n<\/div><\/div>\n<p> <a href=\"https:\/\/www.google.com\/calendar\/event?eid=N2JlZTU3NjEzdW1jYW8ydm01NGpycWtkaGggZmhmaDgyYnVqZDBjZGJxamc4N2Q3aXU4ajRAZw&#038;ctz=Europe\/Paris\" target=\"_blank\" >Voir plus de d\u00e9tails<\/a><\/p><\/div>\n\t<\/li>\n<\/ul>\n\n<\/dd>\n<\/dl><div class=\"simcal-ajax-loader simcal-spinner-top\" style=\"display: none;\"><i class=\"simcal-icon-spinner simcal-icon-spin\"><\/i><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>UPCOMING EVENTS All seminars take place usually each Tuesday at 11 am at 11:00 AM in the meeting room &#8220;Philippe Jeanteur &#8220;.<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2415","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/pages\/2415","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/comments?post=2415"}],"version-history":[{"count":11,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/pages\/2415\/revisions"}],"predecessor-version":[{"id":7740,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/pages\/2415\/revisions\/7740"}],"wp:attachment":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media?parent=2415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}