{"id":2699,"date":"2017-12-11T14:27:20","date_gmt":"2017-12-11T13:27:20","guid":{"rendered":"http:\/\/www.igmm.cnrs.fr\/tyrosine-1-de-larn-polymerase-ii-ctd-controle-terminaison-globale-de-transcription-genes-chez-mammiferes\/"},"modified":"2018-01-11T12:55:50","modified_gmt":"2018-01-11T11:55:50","slug":"tyrosine-1-de-larn-polymerase-ii-ctd-controle-terminaison-globale-de-transcription-genes-chez-mammiferes","status":"publish","type":"post","link":"https:\/\/www.igmm.cnrs.fr\/en\/tyrosine-1-de-larn-polymerase-ii-ctd-controle-terminaison-globale-de-transcription-genes-chez-mammiferes\/","title":{"rendered":"Tyrosine-1 of RNA Polymerase II CTD controls global termination of gene transcription in mammals."},"content":{"rendered":"<p><span lang=\"EN-US\">Transcription of eukaryotic genomes requires an efficient termination to avoid pervasive transcript synthesis or interference. Here Shah, Maqbool et al show that tyrosine of RNA Polymerase II are essential for termination control and recruitment of Mediator and Integrator complexes. An unprecedently described massive read-through phenotype is observed when these residues are mutated.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2694 size-full\" src=\"http:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2017\/12\/Capture-d\u2019e\u0301cran-2017-12-11-a\u0300-13.30.03.png\" alt=\"\" width=\"637\" height=\"630\" srcset=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2017\/12\/Capture-d\u2019e\u0301cran-2017-12-11-a\u0300-13.30.03.png 637w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2017\/12\/Capture-d\u2019e\u0301cran-2017-12-11-a\u0300-13.30.03-450x445.png 450w\" sizes=\"auto, (max-width: 637px) 100vw, 637px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h5><strong>To know more<\/strong><\/h5>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1097276517309371\" target=\"_blank\" rel=\"noopener\">Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals<\/a><\/p>\n<p>Shah N, Maqbool MA, Yahia Y, El Aabidine AZ, Esnault C, Forn\u00e9 I, Decker TM, Martin D, Sch\u00fcller R, Krebs , Blum H, Imhof A, Eick D, Andrau JC.<\/p>\n<p><span role=\"menubar\"><a title=\"Molecular cell.\" role=\"menuitem\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Tyrosine-1+of+RNA+Polymerase+II+CTD+Controls+Global+Termination+of+Gene+Transcription+in+Mammals#\" target=\"_blank\" rel=\"noopener\" aria-expanded=\"false\" aria-haspopup=\"true\">Mol Cell.<\/a><\/span>\u00a02018 Jan 4;69(1):48-61.e6. doi: 10.1016\/j.molcel.2017.12.009.<\/p>\n<p>&nbsp;<\/p>\n<h5><strong>Contact<\/strong><\/h5>\n<p><strong>Jean-Christophe Andrau<\/strong><br \/>\nInstitut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier<br \/>\nCNRS UMR5535 \u2013 Universit\u00e9 de Montpellier<br \/>\n1919 Route de Mende<br \/>\n34293 Montpellier cedex 5<br \/>\nEmail: <a href=\"mailto:jean-christophe.andrau@igmm.cnrs.fr\" rel=\"noopener\">jean-christophe.andrau@igmm.cnrs.fr<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Transcription of eukaryotic genomes requires an efficient termination to avoid pervasive transcript synthesis or interference. Here Shah, Maqbool et al show that tyrosine of RNA Polymerase II are essential for termination control and recruitment of Mediator and Integrator complexes. An unprecedently described massive read-through phenotype is observed when these residues are mutated.<\/p>\n","protected":false},"author":2,"featured_media":2689,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-2699","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-en"],"_links":{"self":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/2699","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/comments?post=2699"}],"version-history":[{"count":7,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/2699\/revisions"}],"predecessor-version":[{"id":2854,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/2699\/revisions\/2854"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media\/2689"}],"wp:attachment":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media?parent=2699"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/categories?post=2699"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/tags?post=2699"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}