{"id":2866,"date":"2018-01-13T10:25:15","date_gmt":"2018-01-13T09:25:15","guid":{"rendered":"http:\/\/www.igmm.cnrs.fr\/recherche-instructions-regulation-de-lexpression-genes-composition-nucleotidique\/"},"modified":"2018-01-13T10:35:07","modified_gmt":"2018-01-13T09:35:07","slug":"recherche-instructions-regulation-de-lexpression-genes-composition-nucleotidique","status":"publish","type":"post","link":"https:\/\/www.igmm.cnrs.fr\/en\/recherche-instructions-regulation-de-lexpression-genes-composition-nucleotidique\/","title":{"rendered":"Probing instructions for expression regulation in gene nucleotide compositions."},"content":{"rendered":"
Identifying a maximum of DNA determinants implicated in gene regulation will accelerate genetic analyses and precision medicine approaches by identifying key gene features. In that context decoding the sequence-level instructions for gene regulation is of prime importance. Among global efforts to achieve this objective, we propose a novel approach able to explain gene expression in each patient sample using only DNA features.<\/div>\n
Our approach, which is as accurate as methods based on epigenetics data, reveals a strong influence of the nucleotide content of gene body sequences, in particular introns. In contrast to canonical regulations mediated by specific DNA motifs, our model unveils a contribution of global nucleotide content notably in co-regulations associated with genome 3D architecture and to associations of genes within topologically associated domains. Overall our study confirms and takes advantage of the existence of sequence-level instructions for gene expression, which lie in genomic regions largely underestimated in regulatory genomics but which appear to be linked to chromatin architecture.<\/div>\n
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To know more<\/strong><\/h5>\n<\/div>\n
Bessi\u00e8re C, Taha M, Petitprez F, Vandel J, Marin JM, Br\u00e9h\u00e9lin L, L\u00e8bre S, Lecellier CH.<\/div>\n
Probing instructions for expression regulation in gene nucleotide compositions.<\/div>\n
PLoS Comput Biol. 2018 Jan 2;14(1):e1005921. doi:10.1371\/journal.pcbi.1005921. PubMed PMID: 29293496.<\/a><\/div>\n

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The team : MicroRNAs biogenesis<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"

Identifying a maximum of DNA determinants implicated in gene regulation will accelerate genetic analyses and precision medicine approaches by identifying key gene features. In that context decoding the sequence-level instructions for gene regulation is of prime importance. Among global efforts to achieve this objective, we propose a novel approach able to explain gene expression in each patient sample using only … Continue reading Probing instructions for expression regulation in gene nucleotide compositions.<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":2856,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-2866","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-en"],"_links":{"self":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/2866","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/comments?post=2866"}],"version-history":[{"count":2,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/2866\/revisions"}],"predecessor-version":[{"id":2868,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/2866\/revisions\/2868"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media\/2856"}],"wp:attachment":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media?parent=2866"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/categories?post=2866"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/tags?post=2866"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}