{"id":3133,"date":"2018-04-19T14:19:03","date_gmt":"2018-04-19T12:19:03","guid":{"rendered":"http:\/\/www.igmm.cnrs.fr\/?p=3133"},"modified":"2018-04-19T14:37:06","modified_gmt":"2018-04-19T12:37:06","slug":"epigenetic-regulation-of-imprinted-genes","status":"publish","type":"post","link":"https:\/\/www.igmm.cnrs.fr\/en\/epigenetic-regulation-of-imprinted-genes\/","title":{"rendered":"Epigenetic Regulation of Imprinted Genes"},"content":{"rendered":"<p>In their study in Cell reports, Ildem Sanli and her co-workers (Robert Feil lab) explore the epigenetic mechanisms involved in the mono-allelic expression of imprinted genes in mammals. The research focuses on a large chromosomal domain in the mouse. Besides the essential expression of a long non-coding RNA (called Meg3), also the Polycomb Repressive Complex-2 is found to be important for imprinted gene expression during development. Based on these insights, the authors propose a new model for imprinting regulation.<img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3120 aligncenter\" src=\"http:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2018\/04\/RFL-PUBLI-2018-450x300.jpg\" alt=\"\" width=\"450\" height=\"300\" srcset=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2018\/04\/RFL-PUBLI-2018-450x300.jpg 450w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2018\/04\/RFL-PUBLI-2018-272x182.jpg 272w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2018\/04\/RFL-PUBLI-2018.jpg 523w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><strong>To know more<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29641995\">Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis.<\/a><\/p>\n<p>Sanli, I., Lalev\u00e9e, S., Camissa, M., Perrin, A., Rage, F., Riccio, A., Ll\u00e8res, D., Bertrand, E., Feil, R.<\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124718303863?via%3Dihub\">Cell reports<\/a> (2018), <a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2018.03.044\">https:\/\/doi.org\/10.1016\/j.celrep.2018.03.044<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In their study in Cell reports, Ildem Sanli and her co-workers (Robert Feil lab) explore the epigenetic mechanisms involved in the mono-allelic expression of imprinted genes in mammals. The research focuses on a large chromosomal domain in the mouse. Besides the essential expression of a long non-coding RNA (called Meg3), also the Polycomb Repressive Complex-2 is found to be important &hellip; <a href=\"https:\/\/www.igmm.cnrs.fr\/en\/epigenetic-regulation-of-imprinted-genes\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Epigenetic Regulation of Imprinted Genes<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":3120,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,16],"tags":[],"class_list":["post-3133","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-news","category-science-en"],"_links":{"self":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/3133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/comments?post=3133"}],"version-history":[{"count":4,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/3133\/revisions"}],"predecessor-version":[{"id":3144,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/3133\/revisions\/3144"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media\/3120"}],"wp:attachment":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media?parent=3133"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/categories?post=3133"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/tags?post=3133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}