{"id":5758,"date":"2021-05-04T15:26:06","date_gmt":"2021-05-04T13:26:06","guid":{"rendered":"https:\/\/www.igmm.cnrs.fr\/?p=5758"},"modified":"2021-05-07T09:20:11","modified_gmt":"2021-05-07T07:20:11","slug":"5758","status":"publish","type":"post","link":"https:\/\/www.igmm.cnrs.fr\/en\/5758\/","title":{"rendered":"Lighting up the central dogma in living embryos: imaging transcription and translation and their spatio-temporal dynamics."},"content":{"rendered":"<div id=\"pl-5758\"  class=\"panel-layout\" ><div id=\"pg-5758-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-5758-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-5758-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h3 class=\"widget-title\"> Lighting up the central dogma in living embryos: imaging transcription and translation and their spatio-temporal dynamics<\/h3>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h6>Quantifying translation in space and time during development<\/h6>\n<p>During development, precise control of gene expression allows the reproducible establishment of patterns, leading to the formation of organs at the right time and place.<\/p>\n<p>The establishment of developmental patterns has been primarily studied at the transcriptional level. In comparison, the fate of these transcripts received little attention.<\/p>\n<p>Dufourt*, Bellec* et al deployed the SunTag labeling method to image the dynamics of translation of individual mRNA molecules in living <em>Drosophila <\/em>embryos. This led to the discovery of translation factories and unmasked important heterogeneities in the efficiency of translation between identical mRNAs, demonstrating a novel layer of fine-tuning of gene expression.<\/p>\n<div class=\"\"><\/div>\n<div class=\"\"><em><a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33927056\/\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"result_click\" data-ga-action=\"2\" data-ga-label=\"33927056\" data-full-article-url=\"from_term=Lagha+M&amp;from_filter=datesearch.y_1&amp;from_pos=2\" data-article-id=\"33927056\">Imaging translation dynamics in live embryos reveals spatial heterogeneities.<\/a><\/em><\/div>\n<div class=\"\">\n<div class=\"docsum-wrap\">\n<div class=\"docsum-content\">\n<div class=\"full-citation docsum-citation\"><em><span class=\"docsum-authors full-authors\">Dufourt J, Bellec M, Trullo A, Dejean M, De Rossi S, Favard C, <b class=\"\">Lagha M.<\/b><\/span>\u00a0<\/em><\/div>\n<div class=\"full-citation docsum-citation\"><em><span class=\"full-journal-citation docsum-journal-citation\">Science. 2021 Apr 29:eabc3483. doi: 10.1126\/science.abc3483. Online ahead of print.<\/span><\/em><\/div>\n<div class=\"full-citation docsum-citation\"><em><span class=\"citation-part\">PMID: <span class=\"docsum-pmid\">33927056<\/span><\/span><\/em><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><div id=\"panel-5758-0-0-1\" class=\"so-panel widget widget_media_video panel-last-child\" data-index=\"1\" ><div style=\"width:100%;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-5758-1\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2021\/05\/TWEETOS-4.mp4?_=1\" \/><source type=\"video\/mp4\" src=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2021\/05\/TWEETOS-4.mp4?_=1\" \/><a href=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2021\/05\/TWEETOS-4.mp4\">https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2021\/05\/TWEETOS-4.mp4<\/a><\/video><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>During development, precise control of gene expression allows &#8230;.<\/p>\n","protected":false},"author":4,"featured_media":5795,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,16],"tags":[],"class_list":["post-5758","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-news","category-science-en"],"_links":{"self":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/5758","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/comments?post=5758"}],"version-history":[{"count":11,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/5758\/revisions"}],"predecessor-version":[{"id":5808,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/5758\/revisions\/5808"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media\/5795"}],"wp:attachment":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media?parent=5758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/categories?post=5758"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/tags?post=5758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}