{"id":6781,"date":"2022-02-08T10:44:05","date_gmt":"2022-02-08T09:44:05","guid":{"rendered":"https:\/\/www.igmm.cnrs.fr\/la-detection-d-hepatocytes-infectes-par-le-virus-de-lhepatite-c-mene-a-lidentification-de-golt1b-comme-un-facteur-regulant-la-replication-virale\/"},"modified":"2022-02-08T10:54:15","modified_gmt":"2022-02-08T09:54:15","slug":"la-detection-d-hepatocytes-infectes-par-le-virus-de-lhepatite-c-mene-a-lidentification-de-golt1b-comme-un-facteur-regulant-la-replication-virale","status":"publish","type":"post","link":"https:\/\/www.igmm.cnrs.fr\/en\/la-detection-d-hepatocytes-infectes-par-le-virus-de-lhepatite-c-mene-a-lidentification-de-golt1b-comme-un-facteur-regulant-la-replication-virale\/","title":{"rendered":"GOLT1B Activation in Hepatitis C Virus-Infected Hepatocytes Links ER Trafficking and Viral Replication"},"content":{"rendered":"<p style=\"text-align: justify;\">Butterworth, Gr\u00e9goire and colleagues used single molecule fluorescent in situ hybridization to detect hepatitis C virus (HCV) RNA in liver sections of a patient with hepatocellular carcinoma on hepatitis C background. Laser microdissection followed by RNAseq analysis of clusters of infected hepatocytes revealed HCV-related deregulation of genes expression. This work, carried out in the group led by Urszula Hibner, in collaboration with Edouard Bertrand and Jean-Christophe Andrau \u2018 labs at the IGMM and with Joachim Lupberger\u2019s team in Strasbourg, led to the identification of GOLT1B as a cellular factor important for viral replication.<\/p>\n<p style=\"text-align: justify;\">Butterworth J.*\/ Gr\u00e9goire D.*<sup>&amp;<\/sup>, Peter M., Roca Suarez AA., Desandr\u00e9 G., Simonin Y., Virzi A., Zine El Aabidine A., Guivarch M., Andrau JC., Bertrand E., Assenat E., Lupberger J., Hibner U.<sup>&amp;<\/sup>\u00a0<em>GOLT1B Activation in Hepatitis C Virus-Infected Hepatocytes Links ER Trafficking and Viral Replication<\/em>, <strong>Pathogens<\/strong>, 2022,<strong>\u00a0<\/strong>11,46. https:\/\/\u00a0<a href=\"http:\/\/doi.org\/10.3390\/pathogens11010046\" target=\"_blank\" rel=\"noopener\">doi.org\/10.3390\/pathogens11010046<\/a>.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6778 size-full\" src=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2022\/02\/graphical-abstract-dm.jpg\" alt=\"\" width=\"700\" height=\"425\" srcset=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2022\/02\/graphical-abstract-dm.jpg 700w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2022\/02\/graphical-abstract-dm-450x273.jpg 450w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Butterworth, Gr\u00e9goire and colleagues used single molecule fluorescent in situ hybridization to detect hepatitis C virus (HCV) RNA in liver sections of a patient with hepatocellular carcinoma on hepatitis C background. Laser microdissection followed by RNAseq analysis of clusters of infected hepatocytes revealed HCV-related deregulation of genes expression. This work, carried out in the group led by Urszula Hibner, in &hellip; <a href=\"https:\/\/www.igmm.cnrs.fr\/en\/la-detection-d-hepatocytes-infectes-par-le-virus-de-lhepatite-c-mene-a-lidentification-de-golt1b-comme-un-facteur-regulant-la-replication-virale\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">GOLT1B Activation in Hepatitis C Virus-Infected Hepatocytes Links ER Trafficking and Viral Replication<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":6779,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,16],"tags":[],"class_list":["post-6781","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-news","category-science-en"],"_links":{"self":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/6781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/comments?post=6781"}],"version-history":[{"count":5,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/6781\/revisions"}],"predecessor-version":[{"id":6790,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/6781\/revisions\/6790"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media\/6779"}],"wp:attachment":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media?parent=6781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/categories?post=6781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/tags?post=6781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}