{"id":7330,"date":"2022-08-29T15:38:36","date_gmt":"2022-08-29T13:38:36","guid":{"rendered":"https:\/\/www.igmm.cnrs.fr\/?p=7330"},"modified":"2022-08-29T15:45:14","modified_gmt":"2022-08-29T13:45:14","slug":"some-erv-sequences-contribute-to-endogenous-gene-expression-through-hp1-regulated-long-range-interactions","status":"publish","type":"post","link":"https:\/\/www.igmm.cnrs.fr\/en\/some-erv-sequences-contribute-to-endogenous-gene-expression-through-hp1-regulated-long-range-interactions\/","title":{"rendered":"Some ERV sequences contribute to endogenous gene expression through HP1-regulated long-range interactions"},"content":{"rendered":"<p style=\"text-align: justify;\">About half of the mammalian genome is constituted of repeated elements among which approximatively 10% are derived from endogenous retroviruses (ERVs). These sequences have often been co-opted by the genome to contribute to endogenous gene expression and specific ERVs are known to be reactivated upon loss of HP1 (Heterochromatin Protein 1), a protein family involved in heterochromatin formation. However, the link between the ERVs, the expression of endogenous genes and the HP1 remains unclear.<\/p>\n<p style=\"text-align: justify;\">In this work, by studying two ERVs located upstream mouse genes upregulated upon loss of HP1 (<em>Mbd1<\/em> and <em>Trim24<\/em>), the group of Thierry Forn\u00e9 (IGMM) in collaboration with Florence Cammas (IRCM), has shown that some ERVs behave as putative enhancers forming a chromatin loop with promoters of endogenous genes depending on HP1 expression level. These specific ERVs are characterized by HP1-independent (H3K9me3 and H4K20me3) or HP1-dependent (H3K27me3) heterochromatin marks, as well as by the enhancer specific mark H3K4me1, a peculiar combination that might represent a bookmark of HP1-dependent enhancers, derived from ERVs.<\/p>\n<p style=\"text-align: justify;\">Altogether, these results lead to the identification of a new type of transcriptional regulation, involving the HP1-dependent formation of physical loops between specific ERVs and endogenous genes. To our knowledge, this is the first demonstration of a direct long-range interaction between an ERV-derived sequence and the promoter of an endogenous gene in mammals, as well as the first example of a putative enhancer whose activity is regulated by HP1.<\/p>\n<p style=\"text-align: justify;\"><span style=\"letter-spacing: 0px;\">Calvet, S. Sallis, N. Saksouk, C. Rebouissou, C. Teyssier, A. Lesne, F. Cammas and T. <\/span><strong style=\"letter-spacing: 0px;\">Forn\u00e9*<\/strong><span style=\"letter-spacing: 0px;\"> &#8211; \u201cEndogenous retroviral sequences behave as putative enhancers controlling gene expression through HP1-regulated long-range chromatin interactions\u201d (2022) <\/span><em style=\"letter-spacing: 0px;\">Cells<\/em><span style=\"letter-spacing: 0px;\"> 11:2392.<\/span><\/p>\n<p style=\"text-align: justify;\">\u00a0<a href=\"https:\/\/doi.org\/10.3390\/cells11152392\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/cells11152392<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-7326 size-large\" src=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2022\/08\/TFL-1024x549.jpg\" alt=\"\" width=\"660\" height=\"354\" srcset=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2022\/08\/TFL-1024x549.jpg 1024w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2022\/08\/TFL-450x241.jpg 450w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2022\/08\/TFL-768x412.jpg 768w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2022\/08\/TFL.jpg 1217w\" sizes=\"auto, (max-width: 660px) 100vw, 660px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>About half of the mammalian genome is constituted of repeated elements among which approximatively 10% are derived from endogenous retroviruses (ERVs). These sequences have often been co-opted by the genome to contribute to endogenous gene expression and specific ERVs are known to be reactivated upon loss of HP1 (Heterochromatin Protein 1), a protein family involved in heterochromatin formation. However, the &hellip; <a href=\"https:\/\/www.igmm.cnrs.fr\/en\/some-erv-sequences-contribute-to-endogenous-gene-expression-through-hp1-regulated-long-range-interactions\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Some ERV sequences contribute to endogenous gene expression through HP1-regulated long-range interactions<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":7329,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,16],"tags":[],"class_list":["post-7330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-news","category-science-en"],"_links":{"self":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/7330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/comments?post=7330"}],"version-history":[{"count":1,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/7330\/revisions"}],"predecessor-version":[{"id":7331,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/7330\/revisions\/7331"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media\/7329"}],"wp:attachment":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media?parent=7330"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/categories?post=7330"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/tags?post=7330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}