{"id":9234,"date":"2025-07-23T11:05:51","date_gmt":"2025-07-23T09:05:51","guid":{"rendered":"https:\/\/www.igmm.cnrs.fr\/comment-les-structures-secondaires-de-ladn-indiquent-le-debut-des-genes-pour-linitiation-de-la-transcription\/"},"modified":"2025-07-25T16:28:38","modified_gmt":"2025-07-25T14:28:38","slug":"comment-les-structures-secondaires-de-ladn-indiquent-le-debut-des-genes-pour-linitiation-de-la-transcription","status":"publish","type":"post","link":"https:\/\/www.igmm.cnrs.fr\/en\/comment-les-structures-secondaires-de-ladn-indiquent-le-debut-des-genes-pour-linitiation-de-la-transcription\/","title":{"rendered":"How DNA secondary structures signal gene start sites for transcription initiation"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-family: Arial, sans-serif; font-size: small;\">In a study published in<a href=\"https:\/\/www.nature.com\/articles\/s41588-025-02263-6\" target=\"_blank\" rel=\"noopener\"> Nature Genetics<\/a>, the team of Jean-Christophe Andrau and collaborators demonstrates how DNA secondary structures, particularly G-quadruplexes, help pinpoint where transcription initiation begins. By opening the chromatin, G-quadruplexes define gene promoters in mammalian genomes.<\/span><\/p>\n<p><a href=\"https:\/\/www.insb.cnrs.fr\/fr\/cnrsinfo\/au-dela-de-la-sequence-quand-la-structure-de-ladn-regule-les-genes\">Au-del\u00e0 de la s\u00e9quence : quand la structure de l\u2019ADN r\u00e9gule les g\u00e8nes | CNRS Biologie<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41588-025-02263-6\">G-quadruplexes are promoter elements controlling nucleosome exclusion and RNA polymerase II pausing | Nature Genetics<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9230 aligncenter\" src=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2025\/07\/JCAL-PUBLI-450x320.jpg\" alt=\"\" width=\"450\" height=\"320\" srcset=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2025\/07\/JCAL-PUBLI-450x320.jpg 450w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2025\/07\/JCAL-PUBLI-1024x728.jpg 1024w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2025\/07\/JCAL-PUBLI-768x546.jpg 768w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2025\/07\/JCAL-PUBLI.jpg 1131w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a study published in Nature Genetics, the team of Jean-Christophe Andrau and collaborators demonstrates how DNA&#8230;..<\/p>\n","protected":false},"author":4,"featured_media":9231,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,16],"tags":[],"class_list":["post-9234","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-news","category-science-en"],"_links":{"self":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/9234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/comments?post=9234"}],"version-history":[{"count":4,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/9234\/revisions"}],"predecessor-version":[{"id":9262,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/9234\/revisions\/9262"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media\/9231"}],"wp:attachment":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media?parent=9234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/categories?post=9234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/tags?post=9234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}