{"id":9479,"date":"2025-11-12T10:55:32","date_gmt":"2025-11-12T09:55:32","guid":{"rendered":"https:\/\/www.igmm.cnrs.fr\/nouvel-eclairage-sur-les-causes-de-linflammation-dans-le-syndrome-de-rett\/"},"modified":"2025-11-20T13:18:17","modified_gmt":"2025-11-20T12:18:17","slug":"nouvel-eclairage-sur-les-causes-de-linflammation-dans-le-syndrome-de-rett","status":"publish","type":"post","link":"https:\/\/www.igmm.cnrs.fr\/en\/nouvel-eclairage-sur-les-causes-de-linflammation-dans-le-syndrome-de-rett\/","title":{"rendered":"Nouvel \u00e9clairage sur les causes de l\u2019inflammation dans le syndrome de Rett"},"content":{"rendered":"

Dans une \u00e9tude publi\u00e9e dans Nature Communications <\/a><\/em>et relay\u00e9e par CNRS Biologie<\/a>, l\u2019\u00e9quipe de Nadine Laguette montre que la prot\u00e9ine MeCP2 limite l\u2019activation du r\u00e9cepteur cGAS en pr\u00e9sence d\u2019ADN cytosolique. Ce m\u00e9canisme freine les r\u00e9ponses inflammatoires excessives et r\u00e9v\u00e8le un r\u00f4le cl\u00e9 de MeCP2 dans le syndrome de Rett.<\/p>\n

En savoir plus\u00a0<\/strong>: The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling<\/u>; Hanane Chamma1<\/sup>, Soumyabrata Guha1<\/sup>, Roger Junior Eloiflin1<\/sup>, Adeline Augereau1<\/sup>, Pierre Le Hars1<\/sup>, Moritz Sch\u00fcssler1<\/sup>, Yasmine Messaoud-Nacer1<\/sup>, Mohammad Salma1<\/sup>, Joe McKellar1<\/sup>, Joanna Re1<\/sup>, Morgane Chemarin1<\/sup>, Arnaud Carrier1<\/sup>, Michael A. Disyak1<\/sup>, Clara Taffoni1<\/sup>, Robin Charpentier1<\/sup>, Zo\u00e9 Husson2<\/sup>, Emmanuel Valjent3<\/sup>, Charlotte Andrieu-Soler1,4<\/sup>, Eric Soler1,4<\/sup>, Maria H Christensen5,6<\/sup>, S\u00f8ren R Paludan6,7<\/sup>, Florian I Schmidt5<\/sup>, Daniela Tropea8-10<\/sup>, Karim Majzoub1<\/sup>, Isabelle K. Vila1<\/sup>, and Nadine Laguette1<\/sup>*. Nat Commun. 2025 Nov 7;16(1):9827. doi: 10.1038\/s41467-025-65713-z.<\/a><\/p>\n

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Figure avec une l\u00e9gende : Mecp2, gardien de l\u2019inflammation. En pr\u00e9sence d\u2019ADN double brin dans le cytosol, Mecp2 est d\u00e9plac\u00e9 hors du noyau. Cette prot\u00e9ine interagit avec les ADN double brins dans le cytosol, inhibant leur reconnaissance par le r\u00e9cepteur cGAS et att\u00e9nuant ainsi la r\u00e9ponse inflammatoires qui en d\u00e9coule, notamment caract\u00e9ris\u00e9e par une productions d\u2019interf\u00e9rons (IFN) de type 1. Le d\u00e9placement de MeCP2 va aussi induire une r\u00e9expression d\u2019\u00e9l\u00e9ments transposables (LINE1) qui vont, via l\u2019action de la prot\u00e9ine Orf1p g\u00e9n\u00e9rer de nouveaux substrats d\u2019ADN susceptibles d\u2019activer les r\u00e9ponses inflammatoires d\u00e9pendantes de cGAS.<\/span><\/p>\n<\/div>\n

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\n","protected":false},"excerpt":{"rendered":"

Cette \u00e9tude met en lumi\u00e8re un r\u00f4le in\u00e9dit de MeCP2 comme \u201cfrein\u201d naturel de l\u2019immunit\u00e9 inn\u00e9e, reliant la r\u00e9gulation de la transcription \u00e0 la ma\u00eetrise de l\u2019inflammation – une d\u00e9couverte qui pourrait ouvrir la voie \u00e0 de nouvelles approches th\u00e9rapeutiques dans le syndrome de Rett et au-del\u00e0<\/p>\n","protected":false},"author":4,"featured_media":9473,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,16],"tags":[],"class_list":["post-9479","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-news","category-science-en"],"_links":{"self":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/9479","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/comments?post=9479"}],"version-history":[{"count":4,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/9479\/revisions"}],"predecessor-version":[{"id":9487,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/9479\/revisions\/9487"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media\/9473"}],"wp:attachment":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media?parent=9479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/categories?post=9479"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/tags?post=9479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}