{"id":9652,"date":"2026-03-31T14:29:19","date_gmt":"2026-03-31T12:29:19","guid":{"rendered":"https:\/\/www.igmm.cnrs.fr\/dna-pk-une-proteine-de-reparation-de-ladn-qui-controle-aussi-linflammation\/"},"modified":"2026-04-03T08:20:07","modified_gmt":"2026-04-03T06:20:07","slug":"dna-pk-une-proteine-de-reparation-de-ladn-qui-controle-aussi-linflammation","status":"publish","type":"post","link":"https:\/\/www.igmm.cnrs.fr\/en\/dna-pk-une-proteine-de-reparation-de-ladn-qui-controle-aussi-linflammation\/","title":{"rendered":"DNA-PK : une prot\u00e9ine de r\u00e9paration de l\u2019ADN qui contr\u00f4le aussi l\u2019inflammation"},"content":{"rendered":"<p style=\"text-align: justify;\" data-start=\"218\" data-end=\"547\">Les travaux de l\u2019\u00e9quipe dirig\u00e9e par Nadine Laguette, men\u00e9s en collaboration avec plusieurs partenaires et publi\u00e9s dans <a href=\"https:\/\/rupress.org\/jem\/article\/223\/5\/e20251796\/281674\/DNA-PK-interacts-with-cyclic-dinucleotides-and\" target=\"_blank\" rel=\"noopener\"><em data-start=\"328\" data-end=\"362\">Journal of Experimental Medicine<\/em><\/a>, mettent en \u00e9vidence un r\u00f4le in\u00e9dit de <strong data-start=\"402\" data-end=\"412\">DNA-PK.<\/strong><\/p>\n<p style=\"text-align: justify;\" data-start=\"218\" data-end=\"547\">Connue pour r\u00e9parer l\u2019ADN, cette prot\u00e9ine agit aussi comme un r\u00e9gulateur cl\u00e9 de l\u2019inflammation en modulant la voie cGAS-STING. Une d\u00e9couverte qui ouvre de nouvelles perspectives th\u00e9rapeutiques.<\/p>\n<p data-start=\"447\" data-end=\"620\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-9647 size-full aligncenter\" style=\"font-weight: bold; background-color: transparent; color: #707070; text-align: inherit; letter-spacing: 0px;\" src=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2026\/03\/Figure_Laguette-Web.jpg\" alt=\"\" width=\"800\" height=\"408\" srcset=\"https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2026\/03\/Figure_Laguette-Web.jpg 800w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2026\/03\/Figure_Laguette-Web-450x230.jpg 450w, https:\/\/www.igmm.cnrs.fr\/wp-content\/uploads\/2026\/03\/Figure_Laguette-Web-768x392.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/p>\n<p style=\"text-align: center;\">\u00a9 Pierre Le Hars<\/p>\n<p style=\"text-align: justify;\" data-start=\"549\" data-end=\"595\"><strong>En savoir plus :\u00a0<\/strong> Vila IK, Messaoud-Nacer Y, Taffoni C, Jardine J, Eloiflin RJ, Augereau A, Guha S, Schussler M, Le Hars P, McKellar J, Carvalho T, Postal J, Chemarin M, Re J, Guivel-Benhassine F, Lopez R, Trillet K, Barrat J, Serbier M, El Mansouri I, Luchsinger C, Chrousos GP, Porrot F, Diaz-Griffero F, Schwartz O, Blanchet FP, Majzoub K, Bid\u00e8re N, Vlachakis D, Laguette N. DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses. J Exp Med. 2026 May 4;223(5):e20251796. doi:\u00a0<a class=\"ext\" title=\"(opens in a new window)\" href=\"https:\/\/rupress.org\/jem\/article\/223\/5\/e20251796\/281674\/DNA-PK-interacts-with-cyclic-dinucleotides-and\" target=\"_blank\" rel=\"noreferrer noopener\" data-extlink=\"\">10.1084\/jem.20251796<\/a>. Epub 2026 Mar 24. PMID: 41874365; PMCID: PMC13011919.<\/p>\n<p data-start=\"549\" data-end=\"595\"><a href=\"https:\/\/www.insb.cnrs.fr\/fr\/cnrsinfo\/dna-pk-une-proteine-de-reparation-de-ladn-qui-controle-aussi-linflammation\" target=\"_blank\" rel=\"noopener\">DNA-PK : une prot\u00e9ine de r\u00e9paration de l\u2019ADN qui contr\u00f4le aussi l\u2019inflammation | CNRS Biologie<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DNA-PK, connue pour r\u00e9parer l\u2019ADN, r\u00e9gule aussi l\u2019inflammation via la voie cGAS-STING, selon une \u00e9tude du groupe de Nadine Laguette (Journal of Experimental Medicine).<\/p>\n","protected":false},"author":4,"featured_media":9648,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,16],"tags":[],"class_list":["post-9652","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-news","category-science-en"],"_links":{"self":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/9652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/comments?post=9652"}],"version-history":[{"count":10,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/9652\/revisions"}],"predecessor-version":[{"id":9675,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/posts\/9652\/revisions\/9675"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media\/9648"}],"wp:attachment":[{"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/media?parent=9652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/categories?post=9652"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.igmm.cnrs.fr\/en\/wp-json\/wp\/v2\/tags?post=9652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}