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Career Outside Academia Seminar: Dr Jona Karam (clinical research associate chez THT bio-science)
4 février 2026 11 h 00 min - 12 h 00 min
Career Outside Academia Seminar: Dr Jona Karam (clinical research associate chez THT bio-science)
Marcel Dorée Seminar Room, CRBM
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Annual Symposium of the Infection & Immunity Axis, BIOLuM: Interferons in Health and disease
5 février 2026 8 h 40 min - 19 h 30 min
Annual Symposium of the Infection & Immunity Axis, BIOLuM: Interferons in Health and disease
Organizers: NadineLaguette, Caroline Goujon, Isabelle Vila, Lise Chauveau & Eric Martinez
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Thesis Defense: Valentin Gonay (CRBM)
9 février 2026 14 h 00 min - 15 h 00 min
Thesis Defense: Valentin Gonay (CRBM)
Amphi Balard
"Machine learning model and other computational approaches to predict the balance of protein aggregation, gelation and solubility"
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Aurélie DIMAN, Université de Genève, Suisse
10 février 2026 11 h 00 min - 12 h 30 min
Aurélie DIMAN, Université de Genève, Suisse
Institut de Génétique Moléculaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France
IGMM External Seminar
Too knotty to resist: Twisted DNA behavior attracts Smc5/6
Contact :nadine.laguette@igmm.cnrs.fr
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Nicolas Gompel (University of Bonn, Germany)
12 février 2026 11 h 00 min - 12 h 30 min
Nicolas Gompel (University of Bonn, Germany)
Institut de Génétique Moléculaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France
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Ciigales Science Coffee Talk
12 février 2026 13 h 00 min - 14 h 00 min
Ciigales Science Coffee Talk
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SaraH Sanders (The Stowers Institute for Medical Research, Kansas City, MO, USA)
13 février 2026 11 h 00 min - 12 h 00 min
SaraH Sanders (The Stowers Institute for Medical Research, Kansas City, MO, USA)
Ph. Jeanteur Seminar Room, IGMM
CRBM external seminar
wtf evolution
Contact: dominique.helmlinger@crbm.cnrs.fr
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Eitan-Erez ZAHAVI, Weizmann Institute of Sciences, Israël
17 février 2026 11 h 00 min - 12 h 30 min
Eitan-Erez ZAHAVI, Weizmann Institute of Sciences, Israël
Institut de Génétique Moléculaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, France
Title : "The hidden SINEs of recovery"
Contact : jean-christophe.andrau@igmm.cnrs.fr
"The hidden SINEs of recovery"
Repeat element RNAs integrate neuronal growth after injury
Neuronal growth and regeneration are regulated by specific genetranscription and translation programs that integrate mRNA localization, localprotein synthesis, retrograde signaling and transcription factor (TF) activity.While the role of protein coding genes in these processes is well studied, thatof regulatory RNAs is little understood. In a screen to identify RNApolyadenylation changes in mouse dorsal root ganglia (DRG) sensory neuronsfollowing sciatic nerve injury, we found the upregulation of polyadenylatedB2-SINE repeat elements. Employing long-read paired-end RNA-seq and ATAC-seqanalyses we pinpointed the upregulation to a subset of B2-SINE loci thatundergo injury-induced chromatin accessible remodeling. This transcriptionalupregulation was specific to injured peripheral sensory neurons and did notoccur retinal ganglion cells following optic nerve crush. Importantly,expression of B2-SINE RNA in retinal and cortical neurons, whose intrinsicability to regenerate is poorer than that of DRG neurons, significantlyimproved their regrowth after nerve injury. Hence, we termed this subset ofinjury-induced, DRG specific elements GI-SINE (growth-inducing B2-SINE).GI-SINEs are induced as discrete transcriptional units from theinjury-activated and pro-regenerative ATF3 and other AP-1 TFs associated loci.GI-SINE RNA interacts with ribosomal proteins and nucleolin, anaxon-growth-regulating RNA binding protein, to regulate translation in neuronalcytoplasm. Finally, antisense oligos against GI-SINEs perturb sensory neuronoutgrowth and nucleolin-ribosome interactions. Thus, we identify a subfamily oftransposable element RNAs that is integral in a signaling circuit regulatingneuronal regrowth, suggesting similar elements can be utilized as regulatedregenerative effectors in other physiological contexts.
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Bill EARNSHAW (Univ Edinburgh, Scotland, UK)
19 février 2026 11 h 00 min - 12 h 00 min
Bill EARNSHAW (Univ Edinburgh, Scotland, UK)
CRBM-CNRS, 1919 Rte de Mende, 34293 Montpellier, France
Conférence invitée CRBM
Salle Marcel Dorée
contact: Claude.prigent@crbm.cnrs.fr
https://earnshawlab.com/prof-bill-earnshaw/
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Ciigales Winter afterwork
19 février 2026 17 h 30 min - 19 h 30 min
Ciigales Winter afterwork
CRBM-IRIM hall/terrace
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