EVENEMENTS A VENIR
Les séminaires externes à l’IGMM ont lieu généralement tous les mardis à 11h00 dans la salle « Philippe Jeanteur ».
- 4 mai 2023
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- 10 mai 2023
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Jean-Emmanuel SARRY (CRCT Toulouse)
10 mai 2023 11 h 00 min - 12 h 30 min
Institut de Génétique Moléculaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, FranceTitle : "Metabolic adaptations driving drug resistance in cancer : from basic studies to clinical perspectives"
Contact : valerie.dardalhon@igmm.cnrs.fr
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- 11 mai 2023
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Marisa Martinez Merino (Univ geneva)
11 mai 2023 11 h 00 min - 12 h 00 min
CNRS-CRBM, 1919 Rte de Mende, 34293 Montpellier, France (salle Marcel Dorée)Marisa Martinez Merino is applying for a PI position at the CRBM
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- 12 mai 2023
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Thomas Gramberg (invited by C Goujon)
12 mai 2023 11 h 00 min - 13 h 00 min
Title: Antiviralintrinsic immunity - targeting old foes andnew enemies
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- 16 mai 2023
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Andrew OLDFIELD (IGH, CNRS Montpellier)
16 mai 2023 11 h 00 min - 12 h 30 min
Institut de Génétique Moléculaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, FranceTitle : “(Un)Conventional paths to establish a cell-type-specific transcriptome”
Contact : etienne.schwob@igmm.cnrs.fr
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- 17 mai 2023
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Team Briant/Battini (Chair: Diana Brychka)
17 mai 2023 11 h 00 min - 13 h 00 min
A new partner for TRIM5α?
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- 25 mai 2023
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Yves Barral (ETH Zurich)
25 mai 2023 11 h 00 min - 12 h 00 min
CNRS-CRBM, 1919 Rte de Mende, 34293 Montpellier, France (salle Marcel Dorée)
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- 26 mai 2023
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Team Muriaux/Favard (Chair: Felipe Leon Diaz)
26 mai 2023 11 h 00 min - 13 h 00 min
Unraveling the Role of F-Actin in SARS-CoV-2 Infection
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- 30 mai 2023
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Rafael GALUPA (CBI, Toulouse-EMBL Heidelberg)
30 mai 2023 11 h 00 min - 12 h 30 min
Institut de Génétique Moléculaire de Montpellier (IGMM), 1919 Rte de Mende, 34090 Montpellier, FranceTitle : "Generating novel patterns of developmental expression from cis-regulatory sequences"
Contact : maud.borensztein@igmm.cnrs.fr
Abstract:
Developmental enhancers bind transcription factors and dictate patterns of gene expression during development. Their molecular evolution can underlie phenotypical evolution, but the contributions of the evolutionary pathways involved remain little understood. We used mutation libraries in Drosophila melanogaster embryos to explore this question, and we observed that most point mutations in developmental enhancers led to changes in gene expression levels but rarely resulted in novel expression outside of the native pattern. In contrast, random sequences often acted as developmental enhancers and drove expression across a range of cell types. Random sequences including motifs for transcription factors with pioneer activity acted as enhancers even more frequently. Our findings suggest that the phenotypic landscapes of developmental enhancers are constrained by enhancer architecture and chromatin accessibility. We propose that the evolution of existing enhancers is limited in its capacity to generate novel phenotypes, whereas the activity of de novo elements is a primary source of phenotypic novelty.
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- 31 mai 2023
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