Agenda

Isabel Chillon (Feil team, IGMM) & Serge Roche (CRBM)

Vous êtes invités au congrès des apprentis chercheurs qui ont été accueillis à l'IRIM et au CRBM !

Contact: claire.lacouture@irim.cnrs.fr

Title : "Molecular Mechanisms of Chromosome Folding and Enhancer Wiring"
Contacts : maud.borensztein@igmm.cnrs.fr - thierry.forne@igmm.cnrs.fr 
 

Elphège obtained his PhD in Paris, working on X-chromosome inactivation and 3D genome conformation at Institut Curie. He then moved to San Francisco for a post-doctoral training at the Gladstone Institute, where he applied genome engineering to study the functions of proteins involved in chromosome organization and gene regulation in embryonic stem cells. He leads now a research group in the Cardiovascular Research Institute at the University of California in San Francisco. He will present recent discoveries from his lab on how cohesin-mediated DNA loop extrusion shapes genome folding. He will also discuss how genomic context determines whether long-range transcriptional control by distal enhancers relies on cohesin loop extrusion during pluripotency and early embryonic lineage commitment.

- New insights into genome folding by loop extrusion from inducible degron technologies. Nat Rev Genet. 2023 Feb;24(2):73-85. de Wit E, Nora EP.  doi: 10.1038/s41576-022-00530-4.

- Molecular basis of CTCF binding polarity in genome folding. Nat Commun. 2020 11 05; 11(1):5612. Nora EP, Caccianini L, Fudenberg G, So K, Kameswaran V, Nagle A, Uebersohn A, Hajj B, Saux AL, Coulon A, Mirny LA, Pollard KS, Dahan M, Bruneau BG. PMID: 33154377; PMCID: PMC7645679.

- Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization. Nora EP, Goloborodko A, Valton AL, Gibcus JH, Uebersohn A, Abdennur N, Dekker J, Mirny LA, Bruneau BG. Cell. 2017 May 18;169(5):930-944.e22. doi: 10.1016/j.cell.2017.05.004. PMID: 28525758; PMCID: PMC5538188.

- Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature. 2012 Apr 11; 485(7398):381-5. Nora EP, Lajoie BR, Schulz EG, Giorgetti L, Okamoto I, Servant N, Piolot T, van Berkum NL, Meisig J, Sedat J, Gribnau J, Barillot E, Blüthgen N, Dekker J, Heard E. PMID: 22495304; PMCID: PMC3555144.

CRBM external seminar, BIOLuM

title : A tale of two lipids: small chemical changes that shape cell membranes
by Dr. Itay BUDIN, Assistant Professor UCSD

Contact: alenka.copic@crbm.cnrs.fr