Institut de Génétique Moléculaire de Montpellier (IGMM) - UMR5535


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The Institute of Molecular Genetics of Montpellier (IGMM) is a multidisciplinary institute for advanced studies in biology. It has an internationally-acknowledged reputation in the fields of genetic and epigenetic regulations, RNA biology as well as cell cycle, death and metabolism. Its work also has impact in biomedical research on cancer, infectious illnesses and genetic diseases via the development of novel biotherapies and diagnostic tools as well as the launching of biotech start-up companies. IGMM is a mixed CNRS/University of Montpellier I & II research unit. It is located on the historical "Route de Mende" CNRS campus of Montpellier and shares numerous programmes and technological platforms with its neighbouring partner Institutes, CRBM and CPBS. Together, the three institutes represent a scientific potential of more than 600 people devoted to research.

Director : Marc PIECHACZYK

In the headlines

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ICR non-coding RNA expression controls imprinting and replication timing at the Dlk1-Dio3 domain.

Genomic imprinting is an epigenetic phenomenon which mediates parent-of-origin specific, mono-allelic gene expression. In a study published in Developmental Cell, the laboratory of Robert Feil explored how imprinted gene expression is regulated at the developmentally-important Dlk1-Dio3 domain. Studying stem cells, they discovered that this process is linked to maternal expression of non-coding RNAs (ncRNAs) from the domain’s ‘Imprinting Control Region’ (ICR). Disruption of the ICR ncRNA (...)

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Tyronise phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells

RNA Polymerase II is a complex made of a number of proteins. The largest protein in this complex includes a ‘carboxy-terminal domain’ that has multiple repeats of seven amino acids one after the other. The first amino acid in each repeat, a tyrosine, is referred to as tyrosine-1. Adding various chemical tags to the amino acids in these repeats co-ordinates the steps involved in the transcription of genes. In yeast, for example, adding a phosphate group to tyrosine-1 seems to help the (...)

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The SUMO pathway : a nouvel therapeutic option for the treatment of Acute Myeloid Leukemia ?

Acute Myleoid Leukemia (AML) are the most frequent leukemia in adults. Their treatment consist of a so-called induction therapy made up of two genotoxic agents: cytarabine (Ara-C) and an antracyclin (daunorubicin or idarubicin). Induction chemotherapy is then followed by a so-called consolidation treatment based on Ara-C only. AML treatments have unfortunately poorly been improved these past 30 years, the problem being agravated by the fact that these leukemia consistute an heterogeneous (...)

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The replication and spindle assembly checkpoints work together to protect chromosomes from precocious mitosis during S phase, Magiera et al. report

Cells obviously have to copy their DNA before they can separate their chromosomes. The DNA replication checkpoint monitors the progress of the first step, and the spindle assembly checkpoint (SAC) permits the second. Researchers are still working out how cells dovetail the end of replication and the beginning of mitosis. If researchers stall DNA synthesis, the replication checkpoint kicks in and halts the cell cycle. Whether this checkpoint is active and stops mitosis under normal (...)

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Institut de Génétique Moléculaire de Montpellier
CNRS-UMR 5535 - 1919, Route de Mende - 34293 Montpellier  Cedex 5
(+33) 04 34 35 96 01