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In the headlines
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How to Start when you are hungry? The yeast Greatwall pathway promotes G1/S transit in poor nutrient conditions |
| Cells decide to undergo, or not, a new division cycle in late G1 at a point called START in yeast or restriction point in mammals. Environmental signals are integrated by multisite phosphorylation of the key transcriptional inhibitor Rb (Whi5 in yeast) by G1 cyclin-dependent kinases. New work from the Schwob lab (Talarek et al., eLife 2017) shows that this transition in yeast is also controlled at the level of the CDK-counteracting phosphatase PP2A. Interestingly, this depends on growth (...) |
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Médaille de l’innovation 2017 du CNRS awarded to Jamal Tazi |
| Jamal Tazi, group leader at the IGMM (RNA metabolism group), is one of four winners of the “Médaille de l’innovation 2017” du CNRS. This prestigious award recognizes exceptional scientific research leading to technological, therapeutic or social innovation. The award ceremony will take place on June 15, 2017 at the Maison des Océans in Paris. |
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Special Seminar Series |
| Pr. Danny REINBERG Professor of Biochemistry and Molecular Pharmacology, New York. University School of Medicine, Smilow Research Center, New York, USA. "Epigenetics: One Genome, Multiple Phenotypes " Friday, June 2 nd, 2017 at 14:00 PM Amphitheater CNRS DR-LR |
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Monitoring chromatin compaction in germ cells |
| How chromatin is structured in cells of living organisms is poorly understood. In a publication in Cell Reports, David Llères and his co-workers adapted a FRET-based microscopic approach to measure nanoscale chromatin compaction. They used this quantitative technology to monitor chromatin compaction in the germline of living C. elegans worms. This collaborative work between the laboratories of Robert Feil (IGMM) and Dimitris Xirodimas (CRBM, Montpellier) reveals heterogeneous compaction (...) |
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A new research group has joined the IGMM |
| A new research group has joined the igmm: the team « Molecular Hematopoiesis » directed by Dr Eric Soler will pursue research on molecular events leading to fine tuning of gene expression in hematopoiesis and associated pathological disorders, with emphasis on long-range genomic interactions. Learn more about their research on their web page (https://www.igmm.cnrs.fr/spip.php?r...), and postdoc / engineer positions available (...) |
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Visualization of single endogenous polysomes reveals the dynamics of translation in live human cells |
| Translation is strictly regulated to control protein levels, expression timing and localization of newly synthesized proteins. As such, translational regulation is essential to quickly respond to environmental changes and is implicated in many diseases including cancer. Certain questions about translation have been unattainable until now. Recently, Edouard Bertrand‘s team published a method to visualize translation of single endogenous mRNPs in live cells. This technology allows measurements (...) |
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Dynamics of nucleosome positioning maturation following genomic replication |
| Chromatin is thought to carry epigenetic information from one generation to the next, although it is unclear how such information survives the disruptions of nucleosomal architecture occurring during genomic replication. The team of Marta Radman-Livaja published in Cell Reports work on a key aspect of chromatin structure dynamics during replication : how rapidly nucleosome positions are established on the newly-replicated daughter genomes. By isolating newly-synthesized DNA marked with (...) |
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Transcriptional memory in drosophila embryos |
| Ferraro et al., provide the first evidence of transcriptional memory in a multicellular organism. By monitoring the expression of stochastically expressed transgenes in living Drosophila embryos, the authors visualize and quantify the extent to which transcription is inherited from mother to daughter cells in a living embryo. Highlights · Live imaging of transcription reveals transcriptional memory in Drosophila embryos. · Memory nuclei exhibit higher probabilities of rapid (...) |
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The cell proliferation antigen Ki-67 controls heterochromatin organisation |
| Ki-67 is a vertebrate cell proliferation antigen, present in the nucleus of all dividing cells. As such, it is the most widely used histopathology marker in cancers. Until now, Ki-67 was thought to be required for cell proliferation. Yet its mechanisms of action in this process had never been pinpointed. The study was conducted by Michal Sobecki, a PhD student of Dan Fisher’s lab, along with local, national and international collaborators. Michal used genome editing to show that Ki-67 is (...) |
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Mounia Lagha, group leader at IGMM, has been awarded a prestigious "Starting Grant" from the European Research Council for her " SYNC Dev" (Synchrony and Development) project |
| Mounia Lagha, group leader at IGMM, has been awarded a prestigious "Starting Grant" from the European Research Council for her " SYNC Dev" (Synchrony and Development) project, which aims at understanding the importance of transcriptional coordination during early development of drosophila. (all results and informations at http://erc.europa.eu). Learn more about Lagha ’s lab research work : (...) |
Seminars and Scientific Meetings
Mardi 12 septembre, 11h00, salle de Séminaire IGMM Dr Gael Cristofari (INSERM, IRCAN, (...)
Open Positions: Internships, PhD Thesis, Post-Docs, Technicians, Engineers
IGMM has a long-standing tradition of training by and for research. Thus, all groups are used (...)