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In the headlines
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IGMM - SIRIC Joint Seminar |
| David GILBERT, PhD Professor of Molecular Biology, Florida State University "Developmental Control of Replication Timing & Chromosome Architecture" Wednesday Sept. 14th, 2016 (11:00 am) Amphithéâtre CNRS - Délégation Régionale |
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Dynamics of nucleosome positioning maturation following genomic replication |
| Chromatin is thought to carry epigenetic information from one generation to the next, although it is unclear how such information survives the disruptions of nucleosomal architecture occurring during genomic replication. The team of Marta Radman-Livaja published in Cell Reports work on a key aspect of chromatin structure dynamics during replication : how rapidly nucleosome positions are established on the newly-replicated daughter genomes. By isolating newly-synthesized DNA marked with (...) |
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Transcriptional memory in drosophila embryos |
| Ferraro et al., provide the first evidence of transcriptional memory in a multicellular organism. By monitoring the expression of stochastically expressed transgenes in living Drosophila embryos, the authors visualize and quantify the extent to which transcription is inherited from mother to daughter cells in a living embryo. Highlights · Live imaging of transcription reveals transcriptional memory in Drosophila embryos. · Memory nuclei exhibit higher probabilities of rapid (...) |
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The cell proliferation antigen Ki-67 controls heterochromatin organisation |
| Ki-67 is a vertebrate cell proliferation antigen, present in the nucleus of all dividing cells. As such, it is the most widely used histopathology marker in cancers. Until now, Ki-67 was thought to be required for cell proliferation. Yet its mechanisms of action in this process had never been pinpointed. The study was conducted by Michal Sobecki, a PhD student of Dan Fisher’s lab, along with local, national and international collaborators. Michal used genome editing to show that Ki-67 is (...) |
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Mounia Lagha, group leader at IGMM, has been awarded a prestigious "Starting Grant" from the European Research Council for her " SYNC Dev" (Synchrony and Development) project |
| Mounia Lagha, group leader at IGMM, has been awarded a prestigious "Starting Grant" from the European Research Council for her " SYNC Dev" (Synchrony and Development) project, which aims at understanding the importance of transcriptional coordination during early development of drosophila. (all results and informations at http://erc.europa.eu). Learn more about Lagha ’s lab research work : (...) |
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EHMT2 controls DNA methylation at specific genomic sites |
| Auclair, G., Borgel, J., Sanz, L.A., Gilbert, S., Cavelier, P., Forné, T., Girardot, M., Feil, R.* and Weber, M.* (2015). EHMT2 controls DNA methylation at specific genomic sites during mouse embryogenesis. (* co-corresponding). Genome Research, Epub ahead of print. Methylation of the histone proteins of chromatin plays diverse roles in gene expression, cell biology and development. The lysine methyltransferase EHMT2 (also called G9A) is essential for embryonic development and controls (...) |
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Nutrients regulate T Cell differentiation |
| T cell activation is associated with increased metabolic needs, and T cell subsets display different metabolic profiles, but whether the extracellular nutrient environment regulates differentiation of cells has been unclear. A new publication by Klysz and colleagues (Naomi Taylor Laboratory) shows how availability of the nutrient glutamine affects the differentiation of T cells. Upon activation, naïve CD4+ T cells proliferate and differentiate into several distinct subtypes. These subtypes (...) |
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A phosphate exporter responsible for brain calcification |
| Phosphate is one of the most abundant anion in the body where it fulfils many key functions: phosphate is a component of nucleic acid molecules and cell membranes, and it plays a crucial role in cellular energy metabolism (ADP and ATP balance) and intracellular signalling (phosphatase and kinase activities). As a consequence, deregulations of phosphate homeostasis are associated with severe pathologies such as the primary familial brain calcification (PFBC), also known as Fahr’s disease. (...) |
Seminars and Scientific Meetings
Two types of seminars are organized on a regular basis at IGMM: (i) weekly internal seminar (...)
Open Positions: Internships, PhD Thesis, Post-Docs, Technicians, Engineers
IGMM has a long-standing tradition of training by and for research. Thus, all groups are used (...)