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In the headlines
Tyronise phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells |
| RNA Polymerase II is a complex made of a number of proteins. The largest protein in this complex includes a ‘carboxy-terminal domain’ that has multiple repeats of seven amino acids one after the other. The first amino acid in each repeat, a tyrosine, is referred to as tyrosine-1. Adding various chemical tags to the amino acids in these repeats co-ordinates the steps involved in the transcription of genes. In yeast, for example, adding a phosphate group to tyrosine-1 seems to help the (...) |
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The SUMO pathway : a nouvel therapeutic option for the treatment of Acute Myeloid Leukemia ? |
| Acute Myleoid Leukemia (AML) are the most frequent leukemia in adults. Their treatment consist of a so-called induction therapy made up of two genotoxic agents: cytarabine (Ara-C) and an antracyclin (daunorubicin or idarubicin). Induction chemotherapy is then followed by a so-called consolidation treatment based on Ara-C only. AML treatments have unfortunately poorly been improved these past 30 years, the problem being agravated by the fact that these leukemia consistute an heterogeneous (...) |
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The replication and spindle assembly checkpoints work together to protect chromosomes from precocious mitosis during S phase, Magiera et al. report |
| Cells obviously have to copy their DNA before they can separate their chromosomes. The DNA replication checkpoint monitors the progress of the first step, and the spindle assembly checkpoint (SAC) permits the second. Researchers are still working out how cells dovetail the end of replication and the beginning of mitosis. If researchers stall DNA synthesis, the replication checkpoint kicks in and halts the cell cycle. Whether this checkpoint is active and stops mitosis under normal (...) |
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Our Colleague Claude Sardet awarded the prestigious "Fondation pour la Recherche Médicale" Rosen prize" |
| Claude Sardet was awarded the "Fondation pour la Recherche Médicale" Rosen prize on November 25, 2013. The "Fondation pour la Recherche Médicale" Raymond Rosen prize is awarded to researchers in Oncology. This year the recipient is Dr. Claude Sardet from the IGMM ("Institut de Génétique Moléculaire de Montpellier", http://www.igmm.cnrs.fr/?lang=en) for his contributions throughout his career. He was officially presented with the prize from the FRM’s president, during a ceremony at the Fondation (...) |
Seminars
External seminars July 2014