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Team Jean-Marie Blanchard - "A novel function for Cyclin A2: Control of cell invasion via RhoA signaling" has been published by The Journal of Cell Biology

Cyclin A2 plays a key role in cell cycle regulation both in S phase and mitosis. It is essential in embryonic cells and in the hematopoietic lineage, yet dispensable in fibroblasts and other adult tissues. In a work published in January 2012 in The Journal of Cell Biology, Nikola Arsic and collaborators demonstrate that Cyclin A2-depleted cells display a cortical distribution of actin filaments and increased migration. These defects are rescued by restoration of wild-type Cyclin A2, which (...)

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Epigenetics and the environment: emerging patterns and implications by Robert Feil and Mario F. Fraga, Nature Reviews Genetics - 4 January 2012

There is considerable interest in exploring whether environmental factors, including chemicals and dietary components, can alter epigenomes. Environmentally induced changes in epigenetic marks are important in the development of several species, such as plants and insects; whether they influence human disease will be an area for future research. http://www.ncbi.nlm.nih.gov/pubmed/...

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New insights into paternal genome regulation

Researchers from the Montpellier Institute of Molecular Genetics (IGMM, CNRS / Montpellier 1 and 2 Universities) just described the mechanism that controls the differential expression of genes according to their parental origin. This work explains why some genes become active only from the maternal copy and some from the paternal copy. This work has been published November 25, 2011 in The EMBO Journal.

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The National Medicine Academy has awarded the Henry and Mary-Jane MITJAVILA Price to Lluis FAJAS COLL, team leader at the IGMM, and to his team for their work on Metabolism and Cancer

This award will be presented during a formal session to be held at the National Academy of Medicine Tuesday, December 20, 2011

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Protein Phosphatase 2A Controls the Order and Dynamics of Cell-Cycle Transitions

Cells of all eukaryotes depend on the activity of a phosphate transfer enzyme, the cyclin-dependent protein kinase Cdk1, to divide. Furthermore, the level of activity of Cdk1 determines the stage of the cell cycle, ie whether the cell will replicate its DNA or enter mitosis. In this paper, Krasinska et al now show that the activity of a serine-threonine phosphatase, PP2A-B55, is a major element of this control network. Mathemetical modelling predicts that a mitotic protein phosphatase (...)

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Art in IGMM

The plurality of languages is a treasure, not a curse. As Georges Steiner said, we should (...)


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