Institut de Génétique Moléculaire de Montpellier (IGMM) - UMR5535


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The Institute of Molecular Genetics of Montpellier (IGMM) is a multidisciplinary institute for advanced studies in biology. It has an internationally-acknowledged reputation in the fields of genetic and epigenetic regulations, RNA biology as well as cell cycle, death and metabolism. Its work also has impact in biomedical research on cancer, infectious illnesses and genetic diseases via the development of novel biotherapies and diagnostic tools as well as the launching of biotech start-up companies. IGMM is a mixed CNRS/University of Montpellier research unit (UMR 5535). It is located on the historical "Route de Mende" CNRS campus of Montpellier and shares numerous programmes and technological platforms with its neighbouring partner Institutes, CRBM and CPBS. Together, the three institutes represent a scientific potential of more than 600 people devoted to research.

Director : Marc PIECHACZYK

In the headlines

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Nutrients regulate T Cell differentiation

T cell activation is associated with increased metabolic needs, and T cell subsets display different metabolic profiles, but whether the extracellular nutrient environment regulates differentiation of cells has been unclear. A new publication by Klysz and colleagues (Naomi Taylor Laboratory) shows how availability of the nutrient glutamine affects the differentiation of T cells. Upon activation, naïve CD4+ T cells proliferate and differentiate into several distinct subtypes. These subtypes (...)

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IGMM recruits new group leaders.

IGMM is a leading research institute in fundamental and translational biology in the south of France. The institute provides an exceptional international environment in the fields of genetic and epigenetic regulation, RNA biology, cancer, immunology and infection. IGMM is recruiting new group leaders to strengthen its research in cancer biology. All proposals with potential synergies to research themes at IGMM will be considered. Particular attention will be paid to projects addressing the (...)

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Hepatitis C viral proteins perturb metabolic liver zonation

Hepatitis C viral (HCV) infection provokes a major remodeling of hepatocyte physiology. One early manifestation of chronic hepatitis C is deregulation of lipid metabolism and the ensuing accumulation of fat droplets in hepatocytes (liver steatosis). This human pathology is reproduced in transgenic mice with liver-targeted expression of physiological levels of the full complement of viral proteins. A recent publication from the group "HCV and Cancer" (Moreau et al. 2015. Hepatitis C viral (...)

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A phosphate exportere responsible for brain calcification

Phosphate is one of the most abundant anion in the body where it fulfils many key functions: phosphate is a component of nucleic acid molecules and cell membranes, and it plays a crucial role in cellular energy metabolism (ADP and ATP balance) and intracellular signalling (phosphatase and kinase activities). As a consequence, deregulations of phosphate homeostasis are associated with severe pathologies such as the primary familial brain calcification (PFBC), also known as Fahr’s disease. (...)

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The SUMO pathway : a nouvel therapeutic option for the treatment of Acute Myeloid Leukemia ?

Acute Myleoid Leukemia (AML) are the most frequent leukemia in adults. Their treatment consist of a so-called induction therapy made up of two genotoxic agents: cytarabine (Ara-C) and an antracyclin (daunorubicin or idarubicin). Induction chemotherapy is then followed by a so-called consolidation treatment based on Ara-C only. AML treatments have unfortunately poorly been improved these past 30 years, the problem being agravated by the fact that these leukemia consistute an heterogeneous (...)

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Seminars and Scientific Meetings

Two types of seminars are organized on a regular basis at IGMM: (i) weekly internal seminar (...)

Open Positions: Internships, PhD Thesis, Post-Docs, Technicians, Engineers

IGMM has a long-standing tradition of training by and for research. Thus, all groups are used (...)

Institut de Génétique Moléculaire de Montpellier
CNRS-UMR 5535 - 1919, Route de Mende - 34293 Montpellier  Cedex 5
(+33) 04 34 35 96 01