We recently showed that the CDK4-pRB-E2F1 cell cycle regulators directly regulate the expression of Kir6.2, which is a key component of the K(ATP) channel involved in the regulation of glucose-induced insulin secretion. There is enough evidence to indicate that the CDK4-pRB-E2F1 regulatory pathway is involved in general glucose homeostasis, and metabolism. In this article we discuss which are the metabolic implications of these findings.
Cell cycle regulators in the control of metabolism
Blanchet, E.; Annicotte, J. S.; Fajas, L.
2009-12-15 / vol 8 / pages 4029-31
1551-4005 (Electronic) 1551-4005 (Linking)
Humans; Animals; Blood Glucose/*metabolism; Cell Cycle/*physiology; Energy Metabolism/*physiology; Adipocytes/*cytology/*metabolism; Cyclin-Dependent Kinase 4/metabolism; E2F1 Transcription Factor/metabolism; Homeostasis/physiology; Lipid Metabolism/physiology