This paper summarizes the contradictory epidemiological data concerning the association between vegetal fibres intake and colorectal cancer incidence. The key to these discrepancies might reside in the different amounts and ratios of butyrate and other short chain fatty acids (SCFA) produced by colonic anaerobic bacteria during fermentation of fibers from different origins, wheat bran fibers being better producers and therefore more protective. Butyrate, an established histone deacetylase inhibitor, acts by favoring an active chromatin configuration of the p21(WAF1/CIP1) gene which, as an inhibitor of cyclin-dependent protein-kinases, block the cell cycle.
Dietary fibre intake and colon cancer
Bulletin Du Cancer
1999-08 / vol 86 / pages 611-613
growth; butyrate; cereal fiber; colorectal-cancer; dietary fibers; epidemiology; fermentation; histone deacetylase; hypertension; nutritional factors; p21(waf1/c1p1) protein; polyps; rat model; short chain fatty acids