The formation of blood cells and vascular networks occurs simultaneously during development, and both lineages remain in close association in all adult tissues. The functional setting of both systems within the embryo and their renewal during adult life are highly complex processes, and require the involvement of numerous molecular actors, the activities of which are often overlapping. Here, I review the activity of TAL-1, a basic-helix-loop-helix transcription factor, which plays a key role in the formation and functioning of both blood and endothelial systems, with a particular emphasis on recent data that associate TAL-1 with angiogenesis.
[The bHLH TAL1 protein: a key molecule in the hematopoietic and endothelial systems]
J Soc Biol
2009 / vol 203 / pages 143-53
10.1051/jbio/2009017 jbio2009017 [pii]
1295-0661 (Print) 1295-0661 (Linking)
Humans; Animals; Mice; Mice, Knockout; Amino Acid Sequence; Models, Molecular; Molecular Sequence Data; *Gene Expression Regulation, Developmental; Protein Conformation; Transcription, Genetic; Adaptor Proteins, Signal Transducing; Adult; Sequence Alignment; Antigens, CD/physiology; Basic Helix-Loop-Helix Transcription; Cadherins/physiology; DNA-Binding Proteins/deficiency/genetics/physiology; Endothelium, Vascular/*physiology; Factors/chemistry/deficiency/genetics/*physiology; Hematopoietic System/embryology/*physiology; LIM Domain Proteins; Metalloproteins/deficiency/genetics/physiology; Multiprotein Complexes; Neovascularization, Physiologic/genetics/*physiology; Proto-Oncogene Proteins/chemistry/deficiency/genetics/*physiology