Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids

Xiaoling Chen 1 2 3 , Jingliang Zhang 1 2 3 , Jiaxiang Wu 1 2 , Morgan J Robinson 1 2 4 , Harish Kothandaraman 5 , Ye-Eun Yoo 1 2 , Iria M Gonzalez Dopeso-Reyes 6 , Thomas D Buffenoir 6 , Manasi S Halurkar 1 2 , Zaiyang Zhang 1 2 , Muhan Wang 1 2 , Erin N Creager 7 , Yuanrui Zhao 1 2 , Maria I Olivero-Acosta 1 2 , Kyle W Wettschurack 1 2 , Zhefu Que 1 2 , Chongli Yuan 2 4 , Allison J Schaser 2 8 , Nadia A Lanman 5 9 , Jean-Christophe Rochet 1 2 , William C Skarnes 10 , Eric J Kremer 6 11 , Yang Yang 1 2 5 11 12

2025

bioRxiv2025 Jun

2025 Jun