Cell cycle regulators in the control of metabolism

Blanchet, E.; Annicotte, J. S.; Fajas, L.

Cell Cycle

2009-12-15 / vol 8 / pages 4029-31


We recently showed that the CDK4-pRB-E2F1 cell cycle regulators directly regulate the expression of Kir6.2, which is a key component of the K(ATP) channel involved in the regulation of glucose-induced insulin secretion. There is enough evidence to indicate that the CDK4-pRB-E2F1 regulatory pathway is involved in general glucose homeostasis, and metabolism. In this article we discuss which are the metabolic implications of these findings.

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10110 [pii]

1551-4005 (Electronic) 1551-4005 (Linking)


Humans; Animals; Blood Glucose/*metabolism; Cell Cycle/*physiology; Energy Metabolism/*physiology; Adipocytes/*cytology/*metabolism; Cyclin-Dependent Kinase 4/metabolism; E2F1 Transcription Factor/metabolism; Homeostasis/physiology; Lipid Metabolism/physiology

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