Inhibition of DNA transcription elongation and unwinding by bis-PNA

Bastide, L.; Villani, G.; Nielsen, P.; Boehmer, P. E.; Lebleu, B.

Nucleosides & Nucleotides

1999 / vol 18 / pages 1669-1671


The possibility to arrest transcription elongation by bis-PNA has been investigated. No arrest of transcription has been obtained in intact cells at variance with the data observed with purified RNA-polymerases. In keeping with these data a purified DNA-helicase (UL9) cannot be fully inhibited by such complexes.



helicase; strand; triple-helix

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