We identified new residues within a 101-amino-acid stretch of the murine leukemia virus capsid that differentially modulate resistance and susceptibility to the mouse Fv1 and human Ref1 genes. Among these residues, aspartate 92 and histidine 117 are both required for Fv1(b) resistance, whereas the latter is sufficient to confer Ref1 resistance.
Residues in the murine leukemia virus capsid that differentially govern resistance to mouse Fv1 and human Ref1 restrictions
Lassaux, A.; Sitbon*, M.; Battini*, J. L.
2005-05 / vol 79 / pages 6560-4
Humans; Animals; Mice; Amino Acid Sequence; Models, Molecular; Molecular Sequence Data; Proteins/*genetics; Cell Line; Sequence Alignment; Capsid Proteins/chemistry/*genetics; DNA-(Apurinic or Apyrimidinic Site) Lyase/*genetics; Genes, Viral/genetics; Leukemia Virus, Murine/*genetics; Restriction Mapping; Retroviridae Infections/*virology; Transfection; Tumor Virus Infections/*virology