Structural correspondences between mouse and human immunoglobulin VH genes. Application to the humanization of mouse monoclonal antibodies

Poul, M. A.; Lefranc, M. P.

Ann N Y Acad Sci

1995-09-29 / vol 764 / pages 359-61

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Humans; Animals; Amino Acid Sequence; Molecular Sequence Data; Species Specificity; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Genetic Engineering; Tumor Cells, Cultured; *Genes, Immunoglobulin; Antibodies, Monoclonal/*genetics/immunology; Antibody Affinity; Immunoglobulin Heavy Chains/chemistry/*genetics; Immunoglobulin Variable Region/chemistry/*genetics; Leukemia-Lymphoma, Adult T-Cell; Mice/*genetics/immunology; Recombinant Fusion Proteins/*genetics/immunology

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