Structure of the murine interferon alpha/beta receptor-encoding gene: high-frequency rearrangements in the interferon-resistant L1210 cell line

Lutfalla, G.; Uze, G.


1994-10-21 / vol 148 / pages 343-6


The structure of the murine IFNAR gene, encoding the interferon alpha/beta receptor, is reported. The gene has eleven exons dispersed in about 23 kb of genomic DNA. The nature of the rearrangements affecting this gene in interferon-resistant (IFNR) L1210 mutant cell lines is described.

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Animals; Mice; Molecular Sequence Data; Tumor Cells, Cultured; Membrane Proteins; Receptor, Interferon alpha-beta; Receptors, Interferon/*genetics; *Gene Rearrangement; Leukemia L1210/*genetics

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