The type I interferon receptor: Structure, function, and evolution of a family business

Mogensen, K. E.; Lewerenz, M.; Reboul, J.; Lutfalla, G.; Uze, G.

Journal of Interferon and Cytokine Research

1999-10 / vol 19 / pages 1069-1098


Recent results indicate that coherent models of how multiple interferons (IFN) are recognized and signal selectively through a common receptor are now feasible, A proposal is made that the IFN receptor, with its subunits IFNAR-1 and IFNAR-2, presents two separate ligand binding sites, and this double structure is both necessary and sufficient to ensure that the different IFN are recognized and can act selectively. The key feature is the duplication of the extracellular domain of the IFNAR-1 subunit and the configurational geometry that this imposes on the intracellular domains of the receptor subunits and their associated tyrosine kinases.



gene-expression; molecular-cloning; signal-transduction; tyrosine phosphorylation; crystal-structure; alpha-beta-receptor; biological-activities; cytokine receptors; gamma receptor; human-leukocyte

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