Translation arrest by RNase H incompetent antisense oligonucleotides

Robbins, I.; Gee, J. E.; Mitta, G.; Rayner, B.; Vichier-Guerre, S.; Leng, M.; Van der Laan, A.; van Boom, J.; Nelson, J. S.; Lebleu, B.

Nucleosides Nucleotides & Nucleic Acids

1999 / vol 18 / pages 1667-1668


Most second-generation ON antisense analogs do not activate RNase H. Alternative strategies to arrest translation in a reticulocyte cell-free assay programmed by VSV mRNAs have been explored.


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