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Redirecting the immune response: role of adoptive T cell therapy

Mondino, A.; Dardalhon, V.; Michelini, R. H.; Loisel-Meyer, S.; Taylor, N.

Hum Gene Ther

2010-05 / vol 21 / pages 533-41

Abstract

Adoptive T cell therapy is aimed at overcoming constraints of the endogenous immune response. In patients with malignancies, this approach is based on the possibility of administering sufficient numbers of tumor-reactive lymphocytes under conditions in which they will promote a therapeutic response. Although this strategy is potentially applicable to a vast number of malignancies, its efficacy, to date, has been limited. This is likely related to several factors including an insufficient persistence and reactivation of infused cells, insufficient tumor infiltration, and the presence of an immunosuppressive environment. Here, we review the importance of pretransplantation host conditioning and posttransplantation strategies that have been shown to contribute to the therapeutic efficacy of infused T lymphocytes.

Lire sur PubMed

10.1089/hum.2010.033

1557-7422 (Electronic) 1043-0342 (Linking)

Étiquettes

Humans; Animals; T-Lymphocytes/*immunology; *Tissue Therapy; Immune System Processes; Lymphocytes/immunology; Neoplasms/*immunology/*therapy

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