AGENDA

Title : Passive Yet Essential, Polycomb Repression in Development and Disease
Contact : carla.heredia@igmm.cnrs.fr

CRBM External Seminar
“Machine Learning and Structure-Based Approaches for the Discovery of Biomarkers and Bioactive Compounds”
Contact: andrey.kajava@crbm.cnrs.fr

Title : “Epigenetic and cis-regulatory determinants of tumorigenesis"
Contact : nadine.laguette@igmm.cnrs.fr

Title: The Genotype–Phenotype Relationship as Mediator of Therapy Resistance in Acute Myeloid Leukemia 

Abstract:
Acute myeloid leukemia (AML) is characterized by extensive genetic and phenotypic heterogeneity. Leukemic stem cells (LSCs) are a self-renewing subpopulation of AML cells that sustains disease initiation, progression, and relapse. By translating the underlying pathogenic genotype into a malignant cellular phenotype and generating the progeny that constitute the bulk of the leukemia, LSCs lie at the interface between genotype and phenotype. Over the past decade, both genetic alterations and cellular phenotypes have emerged as important determinants of therapeutic response in AML. Deciphering how these features interact within LSCs may therefore provide new insights into treatment response, disease persistence, and the development of therapy resistance.

Contact : guillaume.bossis@igmm.cnrs.fr