News – IGMM

Distinct optimal Ras levels are selected in primary tumor and metastases in hepatocellular carcinoma

While it is well established that signal intensity and duration can lead to drastically different outcomes during development, its impact on tumorigenesis remains poorly characterized. In this study supervised by Damien Grégoire and Ula Hibner, our team studied such quantitative heterogeneity of signal intensity in the context of MAPK pathway activation in hepatocellular carcinoma (HCC), the most frequent primary liver … Continue reading Distinct optimal Ras levels are selected in primary tumor and metastases in hepatocellular carcinoma

Montpellier : 50 scientists selected by the FRM “Fondation pour la Recherche Médicale “

Montpellier : 50 chercheurs primés par la Fondation pour la Recherche Médicale – Hérault Tribune (herault-tribune.com) Éric KREMER (2019) : maladies d’Alzheimer, prévenir la maladie d’Alzheimer par un transfert de gène dans le cerveau Ludovic GABELLIER (2019) : cancérologie, explorer une cible thérapeutique dans les leucémies aigües myéloïdes Léo PIOGER (2019) : cancérologie, explorer les dérégulations de l’expression des gènes … Continue reading Montpellier : 50 scientists selected by the FRM “Fondation pour la Recherche Médicale “

Loss of colonic primary cilia promotes inflammation and carcinogenesis

The crosstalk between colonic epithelium and fibroblasts plays a crucial role in colon homeostasis and pathology. An underexplored trait in this cellular dialogue are primary cilia (PC), an antennae‐like structure extruding from the surface of many mammalian cells. PC are cellular organelles serving as sensors of environmental signals. Abnormal ciliary function result in so-called ciliopathies, i.e. inherited disorders, such as … Continue reading Loss of colonic primary cilia promotes inflammation and carcinogenesis

LAUREAT ERC STARTING GRANT 2021: CONGRATULATIONS TO MOUNIA LAGHA

The European Research Council (ERC) has announced the laureates of the Consolidator Grants 2021. The funding will support mid-career researchers and will help them consolidate their teams and conduct pioneering research on topics and with methods of their choosing. One of the ten CNRS laureates is Mounia Lagha for the project : LightRNA2Prot (Spatio-temporal coupling between transcription and translation dynamics … Continue reading LAUREAT ERC STARTING GRANT 2021: CONGRATULATIONS TO MOUNIA LAGHA

Some ERV sequences contribute to endogenous gene expression through HP1-regulated long-range interactions

About half of the mammalian genome is constituted of repeated elements among which approximatively 10% are derived from endogenous retroviruses (ERVs). These sequences have often been co-opted by the genome to contribute to endogenous gene expression and specific ERVs are known to be reactivated upon loss of HP1 (Heterochromatin Protein 1), a protein family involved in heterochromatin formation. However, the … Continue reading Some ERV sequences contribute to endogenous gene expression through HP1-regulated long-range interactions

Genomic distancing in yeast: get out of my DNA !

Social distancing does not apply only to human societies in times of pandemics. The genome of all organisms is a crowded environment in which many machineries concur to read, copy and repair the encoded information. These machineries are susceptible to encounter each other and some of these collisions might interfere with their good functioning, potentially jeopardizing the physiology of the … Continue reading Genomic distancing in yeast: get out of my DNA !

“A fail-safe mechanism to prevent inappropriate genome occupancy”

Timely transcription termination is crucial not only for the correct synthesis of all cellular RNAs but also to confine RNA polymerases to their sites of function. In a study directed by Odil Porrua and Domenico Libri just published in Science Advances the authors unveil a fail-safe termination pathway that prevents RNA polymerases III from “wandering” through the genome, which might jeopardize other processes such as DNA replication or DNA repair.