News – IGMM

Phosphorylation as a phase separation switch during the cell cycle

The cell cycle is driven by cyclin-dependent kinases (CDKs). How the global changes in protein phosphorylation mediated by CDKs promote a rapid and ordered cell reorganisation at mitosis onset has long been a mystery. Here, Valverde, Dubra and a consortium led by the Fisher lab (IGMM) and Altelaar lab (University of Utrecht) show that dynamics of protein phosphorylation in the … Continue reading Phosphorylation as a phase separation switch during the cell cycle

Defending against Dravet

Dravet syndrome (DS), or severe myoclonic epilepsy of infancy, is a rare form of epilepsy affecting less than one in 10,000 people in the United States. However, in affected children, the condition can delay normal development and affect lifelong outcomes. Like many rare diseases, Dravet syndrome still has no cure, but a study recently published in the Journal of Clinical … Continue reading Defending against Dravet

Efficient genome editing in erythroid cells unveils novel MYB target genes and regulatory functions

Efficient genome editing in erythroid cells unveils novel MYB target genes and regulatory functions. Deleuze V, Garcia L, Rouaisnel B, Salma M, Kinoo A, Andrieu-Soler C, Soler E. iScience. 2023 Aug 15;26(9):107641. doi: 10.1016/j.isci.2023.107641. eCollection 2023 Sep 15. DOI: https://doi.org/10.1016/j.isci.2023.107641

Controlling the nucleosome by phosphorylation for DNA repair

Histone post-translational modifications control several fundamental processes on DNA, but very few phosphorylations are known. Here, Fisher, Krasinska and colleagues describe a new phosphorylation of Serine-57 of histone H3, on the globular core. They demonstrate its conservation from yeast to mammals, identify the DNA damage response kinase CHK1 as the major writer in human cells, and show that it loosens … Continue reading Controlling the nucleosome by phosphorylation for DNA repair

SUMOylation controls the rapid transcriptional reprogramming induced by chemotherapies in leukemias

Guillaume Bossis’ team showed in this manuscript published in Nucleic Acids Research that daunorubicin, the main chemotherapeutic drug used for Acute Myeloid Leukemias, a severe blood cancer…

Roche Continents 2023

Zoé Denis, a Ph.D. student in Karim Majzoub’s team at theIGMM, had the opportunity to be part of the Roche-Continents 2023 …

Transcription that (almost) never ends

The team of JC Andrau team has characterized at the genomic scale that a CTD-depleted RNA Polymerase II can still transcribe but cannot terminate transcription anymore. This results in a massive read-through phenotype, over hundreds of kb, at both ends of transcriptional units. Further on, without CTD, Pol II loses its interaction with both Mediator and Integrator complexes that most … Continue reading Transcription that (almost) never ends

G4access reveals that G-quadruplexes are critical for chromatin opening and antagonist to DNA methylation

Dans ce travail, l’équipe de JC Andrau propose une nouvelle approche permettant d’identifier des structures secondaires de l’ADN…..

DOCTORAL GRADUATION CEREMONY

The annual doctoral graduation ceremony for the promotion 2022 of the Montpellier University’s Doctoral College was held on Monday 26 June 2023 at the Corum. Congratulations to Mehuli Chakraborty, Juan de Dios Barba Tena, Jacinthe Mekary, Alexia Pigeot and Amani Wehbi, who did their PhD in our Laboratory.

TAKING CHARGE OF THE METAglut1 BLOOD TEST FOR THE DIAGNOSIS OF DE VIVO DISEASE

The collaboration between several teams from AP-HP, l’IGMM Institut de Génétique Moléculaire de Montpellier (CNRS/Université de Montpellier) and Metafora-Biosystems is a success: for the first time, a diagnostic test, METAglut1, has received a positive decision from Haute Autorité de Santé permitting the reimbursement of its costs by health insurance companies. METAglut1, a fast, reliable blood test, provides an early diagnosis … Continue reading TAKING CHARGE OF THE METAglut1 BLOOD TEST FOR THE DIAGNOSIS OF DE VIVO DISEASE