Environmental effects on genomic imprinting in mammals

Thompson, S. L.; Konfortova, G.; Gregory, R. I.; Reik, W.; Dean, W.; Feil, R.

Toxicology Letters

2001-03-31 / vol 120 / pages 143-150


Genomic imprinting is an epigenetic marking mechanism by which certain genes become repressed on one of the two parental alleles. Imprinting plays important roles in mammalian development, and in humans its deregulation may result in disease and carcinogenesis. During different medical, technological and scientific interventions, pre-implantation embryos and cells are taken from their natural environment and subjected to culture in artificial media. Studies in the mouse demonstrate that environmental stress. such as in vitro culture. can affect the somatic maintenance of epigenetic marks at imprinted loci. These effects are associated with aberrant growth and morphology at fetal and perinatal stages of development. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.


IGMM team(s) involved in this publication

mouse; genomic imprinting; DNA methylation; expression; growth; mice; protein; cells; allele; chromatin conformation; culture; development; embryo culture and manipulation; h19 gene

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