General news

Reimbursement in France for first IVD to help diagnose Glut1 deficiency syndrome

METAglut1TM obtains universal national coverage by French National Health Insurance as of February 22, 2024 after approval by the French National Authority for Health. A fine achievement for the collaborative work of several teams from l’AP-HP, l’IGMM Institut de Génétique Moléculaire de Montpellier (CNRS/Université de Montpellier) and Metafora-Biosystems . METAglut1, a fast, reliable blood test, provides an early diagnosis of … Continue reading Reimbursement in France for first IVD to help diagnose Glut1 deficiency syndrome

30 years of the IGMM

30th Anniversary symposium – celebrating IGMM alumni Institut de Génétique Moléculaire de Montpellier CNRS UMR 5535, University Montpellier 14-15th of March 2024 Amphitheatre of the Delegation regional, 1919 Route de Mende, Montpellier Thursday, March 14th 14:00: Welcoming address by Etienne Schwob, Director of IGMM RNA Biology Chair: Mounia Lagha 14:30: Keynote: Fatima Gebauer, Centre for Genomic Regulation, Barcelona “RNA-binding proteins … Continue reading 30 years of the IGMM

Oncogenic activities of the FGF19 hormone and its analog Aldafermin

In a new publication of the “Tumor heterogeneity in liver cancer” subgroup (D. Gregoire), Ursic-Bedoya, Desandré et al. report a strong oncogenic cooperation between MYC and FGF19 in hepatic carcinogenesis. In addition, they show that a clinically-tested FGF19 analog, Aldafermin (NGM282), retains oncogenic activity.

Entre mère et père, des apports génétiques pas tout à fait équivalents

Pourquoi les apports génétiques entre père et mère diffèrent ?

Phosphorylation as a phase separation switch during the cell cycle

The cell cycle is driven by cyclin-dependent kinases (CDKs). How the global changes in protein phosphorylation mediated by CDKs promote a rapid and ordered cell reorganisation at mitosis onset has long been a mystery. Here, Valverde, Dubra and a consortium led by the Fisher lab (IGMM) and Altelaar lab (University of Utrecht) show that dynamics of protein phosphorylation in the … Continue reading Phosphorylation as a phase separation switch during the cell cycle

Defending against Dravet

Dravet syndrome (DS), or severe myoclonic epilepsy of infancy, is a rare form of epilepsy affecting less than one in 10,000 people in the United States. However, in affected children, the condition can delay normal development and affect lifelong outcomes. Like many rare diseases, Dravet syndrome still has no cure, but a study recently published in the Journal of Clinical … Continue reading Defending against Dravet

Efficient genome editing in erythroid cells unveils novel MYB target genes and regulatory functions

Efficient genome editing in erythroid cells unveils novel MYB target genes and regulatory functions. Deleuze V, Garcia L, Rouaisnel B, Salma M, Kinoo A, Andrieu-Soler C, Soler E. iScience. 2023 Aug 15;26(9):107641. doi: 10.1016/j.isci.2023.107641. eCollection 2023 Sep 15. DOI: https://doi.org/10.1016/j.isci.2023.107641

Controlling the nucleosome by phosphorylation for DNA repair

Histone post-translational modifications control several fundamental processes on DNA, but very few phosphorylations are known. Here, Fisher, Krasinska and colleagues describe a new phosphorylation of Serine-57 of histone H3, on the globular core. They demonstrate its conservation from yeast to mammals, identify the DNA damage response kinase CHK1 as the major writer in human cells, and show that it loosens … Continue reading Controlling the nucleosome by phosphorylation for DNA repair

SUMOylation controls the rapid transcriptional reprogramming induced by chemotherapies in leukemias

Guillaume Bossis’ team showed in this manuscript published in Nucleic Acids Research that daunorubicin, the main chemotherapeutic drug used for Acute Myeloid Leukemias, a severe blood cancer…

Roche Continents 2023

Zoé Denis, a Ph.D. student in Karim Majzoub’s team at theIGMM, had the opportunity to be part of the Roche-Continents 2023 …