Epigenetic Regulation of Imprinted Genes
In their study in Cell reports, Ildem Sanli and her co-workers (Robert Feil lab) explore the epigenetic mechanisms involved in the mono-allelic expression of imprinted genes in mammals. The research focuses on a large chromosomal domain in the mouse. Besides the essential expression of a long non-coding RNA (called Meg3), also the Polycomb Repressive Complex-2 is found to be important … Continue reading Epigenetic Regulation of Imprinted Genes