First 3D images of a giant molecule

Capturing the structure of large molecular complexes with variable shape is an extremely difficult task.

The work group around Prof. Utz Fischer, University Julius-Maximilian of Würzburg (JMU) and  Dr Rémy Bordonné (IGMM) now have been able to do it. Thanks to a new approach, they have succeeded in presenting the first three-dimensional model of the entire SMN complex.

Model of the SMN complex, stained yeast cells can be seen in the background. (Image: Jyotishman Veepaschit / AG Fischer)

Read more:

Identification and structural analysis of the Schizosaccharomyces pombe SMN complex

Jyotishman Veepaschit  Aravindan Viswanathan Rémy Bordonné Clemens GrimmUtz Fischer

Nucleic Acids Res. 2021 Jul 21;49(13):7207-7223. doi: 10.1093/nar/gkab158