Tyrosine-1 of RNA Polymerase II CTD controls global termination of gene transcription in mammals.

Transcription of eukaryotic genomes requires an efficient termination to avoid pervasive transcript synthesis or interference. Here Shah, Maqbool et al show that tyrosine of RNA Polymerase II are essential for termination control and recruitment of Mediator and Integrator complexes. An unprecedently described massive read-through phenotype is observed when these residues are mutated.


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Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals

Shah N, Maqbool MA, Yahia Y, El Aabidine AZ, Esnault C, Forné I, Decker TM, Martin D, Schüller R, Krebs , Blum H, Imhof A, Eick D, Andrau JC.

 2018 Jan 4;69(1):48-61.e6. doi: 10.1016/j.molcel.2017.12.009.



Jean-Christophe Andrau
Institut de Génétique Moléculaire de Montpellier
CNRS UMR5535 – Université de Montpellier
1919 Route de Mende
34293 Montpellier cedex 5