Transcription that (almost) never ends
The team of JC Andrau team has characterized at the genomic scale that a CTD-depleted RNA Polymerase II can still transcribe but cannot terminate transcription anymore. This results in a massive read-through phenotype, over hundreds of kb, at both ends of transcriptional units. Further on, without CTD, Pol II loses its interaction with both Mediator and Integrator complexes that most … Continue reading Transcription that (almost) never ends