The Fondations ARC pour la Recherche sur le Cancer et Jean Paufique (Laboratoire Silab) awarded a prize of 800€ for the best presentations in the “Young Researchers” Poster Competition, during the 18èmes Journées GSO – Montpellier 2022 which were held from November 30 to December 2, 2022 in La Grande Motte, and which gathered nearly 390 participants. From the 108 … Continue reading Concours Posters « Jeunes Chercheurs » Journées GSO 2022
Montpellier : 50 chercheurs primés par la Fondation pour la Recherche Médicale – Hérault Tribune (herault-tribune.com) Éric KREMER (2019) : maladies d’Alzheimer, prévenir la maladie d’Alzheimer par un transfert de gène dans le cerveau Ludovic GABELLIER (2019) : cancérologie, explorer une cible thérapeutique dans les leucémies aigües myéloïdes Léo PIOGER (2019) : cancérologie, explorer les dérégulations de l’expression des gènes … Continue reading Montpellier : 50 scientists selected by the FRM “Fondation pour la Recherche Médicale “
The crosstalk between colonic epithelium and fibroblasts plays a crucial role in colon homeostasis and pathology. An underexplored trait in this cellular dialogue are primary cilia (PC), an antennae‐like structure extruding from the surface of many mammalian cells. PC are cellular organelles serving as sensors of environmental signals. Abnormal ciliary function result in so-called ciliopathies, i.e. inherited disorders, such as … Continue reading Loss of colonic primary cilia promotes inflammation and carcinogenesis
The European Research Council (ERC) has announced the laureates of the Consolidator Grants 2021. The funding will support mid-career researchers and will help them consolidate their teams and conduct pioneering research on topics and with methods of their choosing. One of the ten CNRS laureates is Mounia Lagha for the project : LightRNA2Prot (Spatio-temporal coupling between transcription and translation dynamics … Continue reading LAUREAT ERC STARTING GRANT 2021: CONGRATULATIONS TO MOUNIA LAGHA
About half of the mammalian genome is constituted of repeated elements among which approximatively 10% are derived from endogenous retroviruses (ERVs). These sequences have often been co-opted by the genome to contribute to endogenous gene expression and specific ERVs are known to be reactivated upon loss of HP1 (Heterochromatin Protein 1), a protein family involved in heterochromatin formation. However, the … Continue reading Some ERV sequences contribute to endogenous gene expression through HP1-regulated long-range interactions
Social distancing does not apply only to human societies in times of pandemics. The genome of all organisms is a crowded environment in which many machineries concur to read, copy and repair the encoded information. These machineries are susceptible to encounter each other and some of these collisions might interfere with their good functioning, potentially jeopardizing the physiology of the … Continue reading Genomic distancing in yeast: get out of my DNA !
Most degenerative diseases are caused by the toxicity of protein forming aggregates, for example during Parkinson’s or Alzheimer’s diseases. In this article, Oamen et al discovered that the lipid tripentadecanoin has a strong neuroprotective activity. The toxicity of protein aggregates is largely reduced when neurons are pre or post treated by tripentadecanoin. Using baker’s yeast as a model for cellular … Continue reading Tripentadecanoin, a promising molecule to fight neurodegenerative diseases
Cellular senescence is an irreversible proliferation withdrawal that can be initiated after DNA damage-induced cell cycle arrest in G2 phase to prevent genomic instability caused by aberrant mitoses. Its onset requires p53 (TP53) and retinoblastoma protein (RB1) family tumour suppressors, but how a temporary cell cycle arrest is converted into a permanent one remains unknown. We show that a … Continue reading Reciprocal regulation of p21 and Chk1 controls the Cyclin D1-RB pathway to mediate senescence onset after G2 arrest
