Molecular basis of the cross-talk between chronic inflammation and cancer.* ERG Starting Grant (CrIC; GA #637763) ~ 1.5 M€ ~ 2015-2021 → ERC Proof of Concept 2019: Decreasing Pancreatic Adenocarcinoma-related Inflammation using small molecule inhibitors of STING. ** (DIM-CrIC ; GA #893772) ~150 k€ Synopsis: The CrIC project aimed at identifying the molecular mechanisms at play in the onset and … Continue reading PROJECT
While it is well established that signal intensity and duration can lead to drastically different outcomes during development, its impact on tumorigenesis remains poorly characterized. In this study supervised by Damien Grégoire and Ula Hibner, our team studied such quantitative heterogeneity of signal intensity in the context of MAPK pathway activation in hepatocellular carcinoma (HCC), the most frequent primary liver … Continue reading Distinct optimal Ras levels are selected in primary tumor and metastases in hepatocellular carcinoma
The helicase senataxin (SETX) has been the object of intense investigation since the discovery of its involvement in two unrelated neurodegenerative diseases, almost two decades ago. Recessive mutations in the gene encoding SETX lead to ataxia with oculomotor apraxia, while dominant mutations are associated with a juvenile form of amyotrophic lateral sclerosis. SETX has been involved in different facets of … Continue reading The molecular functions of senataxin are unmasked
Mutations in U4atac, a component of the minor spliceosome, affect the function and the homeostasis of the Integrator, a complex involved in the 3’-end maturation of snRNAs The Taybi-Linder syndrome (MOPD1) is associated with microcephaly and developmental defects and is due to pathogenic variants in the U4atac snRNA, a component of the minor spliceosome which is essential for the … Continue reading Mutations in U4atac
The Fondations ARC pour la Recherche sur le Cancer et Jean Paufique (Laboratoire Silab) awarded a prize of 800€ for the best presentations in the “Young Researchers” Poster Competition, during the 18èmes Journées GSO – Montpellier 2022 which were held from November 30 to December 2, 2022 in La Grande Motte, and which gathered nearly 390 participants. From the 108 … Continue reading Concours Posters « Jeunes Chercheurs » Journées GSO 2022
Montpellier : 50 chercheurs primés par la Fondation pour la Recherche Médicale – Hérault Tribune (herault-tribune.com) Éric KREMER (2019) : maladies d’Alzheimer, prévenir la maladie d’Alzheimer par un transfert de gène dans le cerveau Ludovic GABELLIER (2019) : cancérologie, explorer une cible thérapeutique dans les leucémies aigües myéloïdes Léo PIOGER (2019) : cancérologie, explorer les dérégulations de l’expression des gènes … Continue reading Montpellier : 50 scientists selected by the FRM “Fondation pour la Recherche Médicale “
The crosstalk between colonic epithelium and fibroblasts plays a crucial role in colon homeostasis and pathology. An underexplored trait in this cellular dialogue are primary cilia (PC), an antennae‐like structure extruding from the surface of many mammalian cells. PC are cellular organelles serving as sensors of environmental signals. Abnormal ciliary function result in so-called ciliopathies, i.e. inherited disorders, such as … Continue reading Loss of colonic primary cilia promotes inflammation and carcinogenesis
The European Research Council (ERC) has announced the laureates of the Consolidator Grants 2021. The funding will support mid-career researchers and will help them consolidate their teams and conduct pioneering research on topics and with methods of their choosing. One of the ten CNRS laureates is Mounia Lagha for the project : LightRNA2Prot (Spatio-temporal coupling between transcription and translation dynamics … Continue reading LAUREAT ERC STARTING GRANT 2021: CONGRATULATIONS TO MOUNIA LAGHA
About half of the mammalian genome is constituted of repeated elements among which approximatively 10% are derived from endogenous retroviruses (ERVs). These sequences have often been co-opted by the genome to contribute to endogenous gene expression and specific ERVs are known to be reactivated upon loss of HP1 (Heterochromatin Protein 1), a protein family involved in heterochromatin formation. However, the … Continue reading Some ERV sequences contribute to endogenous gene expression through HP1-regulated long-range interactions
