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Sarah Adele

GOLT1B Activation in Hepatitis C Virus-Infected Hepatocytes Links ER Trafficking and Viral Replication

Butterworth, Grégoire and colleagues used single molecule fluorescent in situ hybridization to detect hepatitis C virus (HCV) RNA in liver sections of a patient with hepatocellular carcinoma on hepatitis C background. Laser microdissection followed by RNAseq analysis of clusters of infected hepatocytes revealed HCV-related deregulation of genes expression. This work, carried out in the group led by Urszula Hibner, in … Continue reading GOLT1B Activation in Hepatitis C Virus-Infected Hepatocytes Links ER Trafficking and Viral Replication

Splicing efficiency of minor introns in a mouse model of SMA predominantly depends on their branchpoint sequence and can involve the contribution of major spliceosome components

ABSTRACT Spinal Muscular Atrophy (SMA) is a devastating neurodegenerative disease caused by reduced amounts of the ubiquitously expressed Survival of Motor Neuron (SMN) protein. In agreement with its crucial role in the biogenesis of spliceosomal snRNPs, SMN-deficiency is correlated to numerous splicing alterations in patient cells and various tissues of SMA mouse models. Among the snRNPs whose assembly is impacted … Continue reading Splicing efficiency of minor introns in a mouse model of SMA predominantly depends on their branchpoint sequence and can involve the contribution of major spliceosome components

LAUREAT ERC Starting grant 2021: Karim MAJZOUB

Karim MAJZOUB selected from 397 scientists for the prestigious Starting Grant from the European Research Council – ERC. The ERC Starting Grants are designed to support excellent Principal Investigators at the career stage at which they are starting their own independent research team or programme. DELV – DELta Virus infection in animal and human hosts : The emergence and rapid transmission … Continue reading LAUREAT ERC Starting grant 2021: Karim MAJZOUB

Three CNRS life scientists join the EMBO Young Investigator Network

EMBO YOUNG INVESTIGATOR 2021 December 8th, 2021 – Among twenty-six life scientists, Mounia Lagha New Member of the European Molecular Biology Organization (EMBO) The EMBO Young Investigator Programme supports life scientists who have an excellent track record and have been group leaders for at least one but less than four years. As part of the programme, EMBO Young Investigators benefit … Continue reading Three CNRS life scientists join the EMBO Young Investigator Network

BETTENCOURT PRIZE “COUPS D’ÉLAN POUR LA RECHERCHE FRANÇAISE”

MOUNIA LAGHA  LAUREATE 2021 « L’expression des gènes au cours du développement : être au bon endroit au bon moment »    The prize was created by the BETTENCOURT Foundation in 2000. Since then, 74 French laboratories and more than 800 researchers have benefited from this prize. This Bettencourt prize, awarded on 23 November 2021, will be used to purchase … Continue reading BETTENCOURT PRIZE “COUPS D’ÉLAN POUR LA RECHERCHE FRANÇAISE”