Sarah Adele
Four CNRS Scientists from Montpellier receive the prestigious ERC grant
Nadine Laguette, winner of the Consolidator 2022 grant for her research project “Charting Cell Type-Specific Nucleic Acid Immunity (SENTINEL)” which aims to study the communication between innate immunity and essential fatty acid metabolism pathways, using adipose tissue as a model. This project will also allow the study of new pathways involved in the regulation of inflammatory responses in … Continue reading Four CNRS Scientists from Montpellier receive the prestigious ERC grant
PROJECT
Molecular basis of the cross-talk between chronic inflammation and cancer.* ERG Starting Grant (CrIC; GA #637763) ~ 1.5 M€ ~ 2015-2021 → ERC Proof of Concept 2019: Decreasing Pancreatic Adenocarcinoma-related Inflammation using small molecule inhibitors of STING. ** (DIM-CrIC ; GA #893772) ~150 k€ Synopsis: The CrIC project aimed at identifying the molecular mechanisms at play in the onset and … Continue reading PROJECT
Distinct optimal Ras levels are selected in primary tumor and metastases in hepatocellular carcinoma
While it is well established that signal intensity and duration can lead to drastically different outcomes during development, its impact on tumorigenesis remains poorly characterized. In this study supervised by Damien Grégoire and Ula Hibner, our team studied such quantitative heterogeneity of signal intensity in the context of MAPK pathway activation in hepatocellular carcinoma (HCC), the most frequent primary liver … Continue reading Distinct optimal Ras levels are selected in primary tumor and metastases in hepatocellular carcinoma
The molecular functions of senataxin are unmasked
The helicase senataxin (SETX) has been the object of intense investigation since the discovery of its involvement in two unrelated neurodegenerative diseases, almost two decades ago. Recessive mutations in the gene encoding SETX lead to ataxia with oculomotor apraxia, while dominant mutations are associated with a juvenile form of amyotrophic lateral sclerosis. SETX has been involved in different facets of … Continue reading The molecular functions of senataxin are unmasked
Mutations in U4atac
Mutations in U4atac, a component of the minor spliceosome, affect the function and the homeostasis of the Integrator, a complex involved in the 3’-end maturation of snRNAs The Taybi-Linder syndrome (MOPD1) is associated with microcephaly and developmental defects and is due to pathogenic variants in the U4atac snRNA, a component of the minor spliceosome which is essential for the … Continue reading Mutations in U4atac
Concours Posters « Jeunes Chercheurs » Journées GSO 2022
The Fondations ARC pour la Recherche sur le Cancer et Jean Paufique (Laboratoire Silab) awarded a prize of 800€ for the best presentations in the “Young Researchers” Poster Competition, during the 18èmes Journées GSO – Montpellier 2022 which were held from November 30 to December 2, 2022 in La Grande Motte, and which gathered nearly 390 participants. From the 108 … Continue reading Concours Posters « Jeunes Chercheurs » Journées GSO 2022
Montpellier : 50 scientists selected by the FRM “Fondation pour la Recherche Médicale “
Montpellier : 50 chercheurs primés par la Fondation pour la Recherche Médicale – Hérault Tribune (herault-tribune.com) Éric KREMER (2019) : maladies d’Alzheimer, prévenir la maladie d’Alzheimer par un transfert de gène dans le cerveau Ludovic GABELLIER (2019) : cancérologie, explorer une cible thérapeutique dans les leucémies aigües myéloïdes Léo PIOGER (2019) : cancérologie, explorer les dérégulations de l’expression des gènes … Continue reading Montpellier : 50 scientists selected by the FRM “Fondation pour la Recherche Médicale “
Loss of colonic primary cilia promotes inflammation and carcinogenesis
The crosstalk between colonic epithelium and fibroblasts plays a crucial role in colon homeostasis and pathology. An underexplored trait in this cellular dialogue are primary cilia (PC), an antennae‐like structure extruding from the surface of many mammalian cells. PC are cellular organelles serving as sensors of environmental signals. Abnormal ciliary function result in so-called ciliopathies, i.e. inherited disorders, such as … Continue reading Loss of colonic primary cilia promotes inflammation and carcinogenesis