Science
Four CNRS Scientists from Montpellier receive the prestigious ERC grant
Nadine Laguette, winner of the Consolidator 2022 grant for her research project “Charting Cell Type-Specific Nucleic Acid Immunity (SENTINEL)” which aims to study the communication between innate immunity and essential fatty acid metabolism pathways, using adipose tissue as a model. This project will also allow the study of new pathways involved in the regulation of inflammatory responses in … Continue reading Four CNRS Scientists from Montpellier receive the prestigious ERC grant
Distinct optimal Ras levels are selected in primary tumor and metastases in hepatocellular carcinoma
While it is well established that signal intensity and duration can lead to drastically different outcomes during development, its impact on tumorigenesis remains poorly characterized. In this study supervised by Damien Grégoire and Ula Hibner, our team studied such quantitative heterogeneity of signal intensity in the context of MAPK pathway activation in hepatocellular carcinoma (HCC), the most frequent primary liver … Continue reading Distinct optimal Ras levels are selected in primary tumor and metastases in hepatocellular carcinoma
The molecular functions of senataxin are unmasked
The helicase senataxin (SETX) has been the object of intense investigation since the discovery of its involvement in two unrelated neurodegenerative diseases, almost two decades ago. Recessive mutations in the gene encoding SETX lead to ataxia with oculomotor apraxia, while dominant mutations are associated with a juvenile form of amyotrophic lateral sclerosis. SETX has been involved in different facets of … Continue reading The molecular functions of senataxin are unmasked
Mutations in U4atac
Mutations in U4atac, a component of the minor spliceosome, affect the function and the homeostasis of the Integrator, a complex involved in the 3’-end maturation of snRNAs The Taybi-Linder syndrome (MOPD1) is associated with microcephaly and developmental defects and is due to pathogenic variants in the U4atac snRNA, a component of the minor spliceosome which is essential for the … Continue reading Mutations in U4atac
Montpellier : 50 scientists selected by the FRM “Fondation pour la Recherche Médicale “
Montpellier : 50 chercheurs primés par la Fondation pour la Recherche Médicale – Hérault Tribune (herault-tribune.com) Éric KREMER (2019) : maladies d’Alzheimer, prévenir la maladie d’Alzheimer par un transfert de gène dans le cerveau Ludovic GABELLIER (2019) : cancérologie, explorer une cible thérapeutique dans les leucémies aigües myéloïdes Léo PIOGER (2019) : cancérologie, explorer les dérégulations de l’expression des gènes … Continue reading Montpellier : 50 scientists selected by the FRM “Fondation pour la Recherche Médicale “
LAUREAT ERC STARTING GRANT 2021: CONGRATULATIONS TO MOUNIA LAGHA
The European Research Council (ERC) has announced the laureates of the Consolidator Grants 2021. The funding will support mid-career researchers and will help them consolidate their teams and conduct pioneering research on topics and with methods of their choosing. One of the ten CNRS laureates is Mounia Lagha for the project : LightRNA2Prot (Spatio-temporal coupling between transcription and translation dynamics … Continue reading LAUREAT ERC STARTING GRANT 2021: CONGRATULATIONS TO MOUNIA LAGHA
Some ERV sequences contribute to endogenous gene expression through HP1-regulated long-range interactions
About half of the mammalian genome is constituted of repeated elements among which approximatively 10% are derived from endogenous retroviruses (ERVs). These sequences have often been co-opted by the genome to contribute to endogenous gene expression and specific ERVs are known to be reactivated upon loss of HP1 (Heterochromatin Protein 1), a protein family involved in heterochromatin formation. However, the … Continue reading Some ERV sequences contribute to endogenous gene expression through HP1-regulated long-range interactions
Genomic distancing in yeast: get out of my DNA !
Social distancing does not apply only to human societies in times of pandemics. The genome of all organisms is a crowded environment in which many machineries concur to read, copy and repair the encoded information. These machineries are susceptible to encounter each other and some of these collisions might interfere with their good functioning, potentially jeopardizing the physiology of the … Continue reading Genomic distancing in yeast: get out of my DNA !