The molecular functions of senataxin are unmasked
The helicase senataxin (SETX) has been the object of intense investigation since the discovery of its involvement in two unrelated neurodegenerative diseases, almost two decades ago. Recessive mutations in the gene encoding SETX lead to ataxia with oculomotor apraxia, while dominant mutations are associated with a juvenile form of amyotrophic lateral sclerosis. SETX has been involved in different facets of … Continue reading The molecular functions of senataxin are unmasked