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Four CNRS Scientists from Montpellier receive the prestigious ERC grant

Nadine Laguette, winner of the Consolidator 2022 grant for her research project “Charting Cell Type-Specific Nucleic Acid Immunity (SENTINEL)” which aims to study the communication between innate immunity and essential fatty acid metabolism pathways, using adipose tissue as a model. This project will also allow the study of new pathways involved in the regulation of inflammatory responses in … Continue reading Four CNRS Scientists from Montpellier receive the prestigious ERC grant

PROJECT

Molecular basis of the cross-talk between chronic inflammation and cancer.* ERG Starting Grant (CrIC; GA #637763) ~ 1.5 M€ ~ 2015-2021 → ERC Proof of Concept 2019: Decreasing Pancreatic Adenocarcinoma-related Inflammation using small molecule inhibitors of STING. ** (DIM-CrIC ; GA #893772) ~150 k€ Synopsis: The CrIC project aimed at identifying the molecular mechanisms at play in the onset and … Continue reading PROJECT

Ce mercredi 12 avril 2023, le Consortium Montpellier Cancer associant l’ICM, le CHU de Montpellier, l’Inserm, le CNRS et les Universités, lance son nouveau projet suite au renouvellement du label SIRIC – « SIte de Recherche Intégrée sur le Cancer » – attribué par l’Institut National du Cancer.

Distinct optimal Ras levels are selected in primary tumor and metastases in hepatocellular carcinoma

While it is well established that signal intensity and duration can lead to drastically different outcomes during development, its impact on tumorigenesis remains poorly characterized. In this study supervised by Damien Grégoire and Ula Hibner, our team studied such quantitative heterogeneity of signal intensity in the context of MAPK pathway activation in hepatocellular carcinoma (HCC), the most frequent primary liver … Continue reading Distinct optimal Ras levels are selected in primary tumor and metastases in hepatocellular carcinoma

Montpellier : 50 scientists selected by the FRM “Fondation pour la Recherche Médicale “

Montpellier : 50 chercheurs primés par la Fondation pour la Recherche Médicale – Hérault Tribune (herault-tribune.com) Éric KREMER (2019) : maladies d’Alzheimer, prévenir la maladie d’Alzheimer par un transfert de gène dans le cerveau Ludovic GABELLIER (2019) : cancérologie, explorer une cible thérapeutique dans les leucémies aigües myéloïdes Léo PIOGER (2019) : cancérologie, explorer les dérégulations de l’expression des gènes … Continue reading Montpellier : 50 scientists selected by the FRM “Fondation pour la Recherche Médicale “

Loss of colonic primary cilia promotes inflammation and carcinogenesis

The crosstalk between colonic epithelium and fibroblasts plays a crucial role in colon homeostasis and pathology. An underexplored trait in this cellular dialogue are primary cilia (PC), an antennae‐like structure extruding from the surface of many mammalian cells. PC are cellular organelles serving as sensors of environmental signals. Abnormal ciliary function result in so-called ciliopathies, i.e. inherited disorders, such as … Continue reading Loss of colonic primary cilia promotes inflammation and carcinogenesis

LAUREAT ERC STARTING GRANT 2021: CONGRATULATIONS TO MOUNIA LAGHA

The European Research Council (ERC) has announced the laureates of the Consolidator Grants 2021. The funding will support mid-career researchers and will help them consolidate their teams and conduct pioneering research on topics and with methods of their choosing. One of the ten CNRS laureates is Mounia Lagha for the project : LightRNA2Prot (Spatio-temporal coupling between transcription and translation dynamics … Continue reading LAUREAT ERC STARTING GRANT 2021: CONGRATULATIONS TO MOUNIA LAGHA