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Some ERV sequences contribute to endogenous gene expression through HP1-regulated long-range interactions

About half of the mammalian genome is constituted of repeated elements among which approximatively 10% are derived from endogenous retroviruses (ERVs). These sequences have often been co-opted by the genome to contribute to endogenous gene expression and specific ERVs are known to be reactivated upon loss of HP1 (Heterochromatin Protein 1), a protein family involved in heterochromatin formation. However, the … Continue reading Some ERV sequences contribute to endogenous gene expression through HP1-regulated long-range interactions

Genomic distancing in yeast: get out of my DNA !

Social distancing does not apply only to human societies in times of pandemics. The genome of all organisms is a crowded environment in which many machineries concur to read, copy and repair the encoded information. These machineries are susceptible to encounter each other and some of these collisions might interfere with their good functioning, potentially jeopardizing the physiology of the … Continue reading Genomic distancing in yeast: get out of my DNA !

“A fail-safe mechanism to prevent inappropriate genome occupancy”

Timely transcription termination is crucial not only for the correct synthesis of all cellular RNAs but also to confine RNA polymerases to their sites of function. In a study directed by Odil Porrua and Domenico Libri just published in Science Advances the authors unveil a fail-safe termination pathway that prevents RNA polymerases III from “wandering” through the genome, which might jeopardize other processes such as DNA replication or DNA repair.

Tripentadecanoin, a promising molecule to fight neurodegenerative diseases

Most degenerative diseases are caused by the toxicity of protein forming aggregates, for example during Parkinson’s or Alzheimer’s diseases. In this article, Oamen et al discovered that the lipid tripentadecanoin has a strong neuroprotective activity. The toxicity of protein aggregates is largely reduced when neurons are pre or post treated by tripentadecanoin. Using baker’s yeast as a model for cellular … Continue reading Tripentadecanoin, a promising molecule to fight neurodegenerative diseases

Reciprocal regulation of p21 and Chk1 controls the Cyclin D1-RB pathway to mediate senescence onset after G2 arrest

  Cellular senescence is an irreversible proliferation withdrawal that can be initiated after DNA damage-induced cell cycle arrest in G2 phase to prevent genomic instability caused by aberrant mitoses. Its onset requires p53 (TP53) and retinoblastoma protein (RB1) family tumour suppressors, but how a temporary cell cycle arrest is converted into a permanent one remains unknown. We show that a … Continue reading Reciprocal regulation of p21 and Chk1 controls the Cyclin D1-RB pathway to mediate senescence onset after G2 arrest

The control of transcriptional memory by stable mitotic bookmarking

New publication from the Lagha lab in Nature Communications, by Bellec et al., 2022 Read More: A voir aussi sur les actualités de l’INSB En direct des labos The control of transcriptional memory by stable mitotic bookmarking Maëlle Bellec, Jérémy Dufourt, George Hunt, Hélène Lenden-Hasse, Antonio Trullo, Amal Zine El Aabidine, Marie Lamarque, Marissa M Gaskill, Heloïse Faure-Gautron, Mattias Mannervik, … Continue reading The control of transcriptional memory by stable mitotic bookmarking

GOLT1B Activation in Hepatitis C Virus-Infected Hepatocytes Links ER Trafficking and Viral Replication

Butterworth, Grégoire and colleagues used single molecule fluorescent in situ hybridization to detect hepatitis C virus (HCV) RNA in liver sections of a patient with hepatocellular carcinoma on hepatitis C background. Laser microdissection followed by RNAseq analysis of clusters of infected hepatocytes revealed HCV-related deregulation of genes expression. This work, carried out in the group led by Urszula Hibner, in … Continue reading GOLT1B Activation in Hepatitis C Virus-Infected Hepatocytes Links ER Trafficking and Viral Replication