Sarah Adele
TAKING CHARGE OF THE METAglut1 BLOOD TEST FOR THE DIAGNOSIS OF DE VIVO DISEASE
The collaboration between several teams from AP-HP, l’IGMM Institut de Génétique Moléculaire de Montpellier (CNRS/Université de Montpellier) and Metafora-Biosystems is a success: for the first time, a diagnostic test, METAglut1, has received a positive decision from Haute Autorité de Santé permitting the reimbursement of its costs by health insurance companies. METAglut1, a fast, reliable blood test, provides an early diagnosis … Continue reading TAKING CHARGE OF THE METAglut1 BLOOD TEST FOR THE DIAGNOSIS OF DE VIVO DISEASE
Four CNRS Scientists from Montpellier receive the prestigious ERC grant
Nadine Laguette, winner of the Consolidator 2022 grant for her research project “Charting Cell Type-Specific Nucleic Acid Immunity (SENTINEL)” which aims to study the communication between innate immunity and essential fatty acid metabolism pathways, using adipose tissue as a model. This project will also allow the study of new pathways involved in the regulation of inflammatory responses in … Continue reading Four CNRS Scientists from Montpellier receive the prestigious ERC grant
PROJECT
Molecular basis of the cross-talk between chronic inflammation and cancer.* ERG Starting Grant (CrIC; GA #637763) ~ 1.5 M€ ~ 2015-2021 → ERC Proof of Concept 2019: Decreasing Pancreatic Adenocarcinoma-related Inflammation using small molecule inhibitors of STING. ** (DIM-CrIC ; GA #893772) ~150 k€ Synopsis: The CrIC project aimed at identifying the molecular mechanisms at play in the onset and … Continue reading PROJECT
Distinct optimal Ras levels are selected in primary tumor and metastases in hepatocellular carcinoma
While it is well established that signal intensity and duration can lead to drastically different outcomes during development, its impact on tumorigenesis remains poorly characterized. In this study supervised by Damien Grégoire and Ula Hibner, our team studied such quantitative heterogeneity of signal intensity in the context of MAPK pathway activation in hepatocellular carcinoma (HCC), the most frequent primary liver … Continue reading Distinct optimal Ras levels are selected in primary tumor and metastases in hepatocellular carcinoma
The molecular functions of senataxin are unmasked
The helicase senataxin (SETX) has been the object of intense investigation since the discovery of its involvement in two unrelated neurodegenerative diseases, almost two decades ago. Recessive mutations in the gene encoding SETX lead to ataxia with oculomotor apraxia, while dominant mutations are associated with a juvenile form of amyotrophic lateral sclerosis. SETX has been involved in different facets of … Continue reading The molecular functions of senataxin are unmasked
Mutations in U4atac
Mutations in U4atac, a component of the minor spliceosome, affect the function and the homeostasis of the Integrator, a complex involved in the 3’-end maturation of snRNAs The Taybi-Linder syndrome (MOPD1) is associated with microcephaly and developmental defects and is due to pathogenic variants in the U4atac snRNA, a component of the minor spliceosome which is essential for the … Continue reading Mutations in U4atac