News – Page 9

HRS-seq : a new genomic method reveals the importance of nuclear bodies in organizing the active chromosomal compartment

In a work published in Genome Research, Marie-Odile Baudement and its colleagues (team « Genome organization and epigenetic control » led by Thierry Forné), have developed the HRS-seq, a new straightforward genome-wide approach whereby they isolated and sequenced genomic regions associated with nuclear bodies and other membrane-less nuclear organelles which are made insoluble through high-salt treatments (HRS – High-salt Recovered … Continue reading HRS-seq : a new genomic method reveals the importance of nuclear bodies in organizing the active chromosomal compartment

A growing toolbox to image gene expression in single cells: sensitive approaches for demanding challenges

This review looks both backward and forward to summarize the available imaging techniques to monitor gene expression at single molecule resolution, in fixed and living cells and embryos

R2TP and R2SP are co-chaperones involved in the assembly of macro-molecular complexes

In a Nature Communications publication, Chloé Maurizy and colleagues (E. Bertrand’s team and 3 other teams from ANR consortium snoRNPASSEMBLY) have discovered a novel co-chaperone, called R2SP. It was known that macromolecular complex assembly requires dedicated machinery working with Hsp90. We and others have shown that R2TP/Hsp90 is involved in assembly of essential complexes such as snoRNPs, snRNPs, RNA polymerases … Continue reading R2TP and R2SP are co-chaperones involved in the assembly of macro-molecular complexes

Neutrophils are essential for induction of vaccine-like effects by antiviral monoclonal antibody immunotherapies.

Monoclonal antibodies (mAbs) are the largest class of biomedicines. Administered to neutralize and eliminate pathogens, they can also induce a lasting immune response, such as vaccination. The work of Mar Naranjo-Gomez et al., In the team “Oncogenesis and Immunotherapy” has demonstrated an unexpected role of a type of leukocytes, neutrophils, in the therapeutic efficacy of mAbs. These cells of the … Continue reading Neutrophils are essential for induction of vaccine-like effects by antiviral monoclonal antibody immunotherapies.

Targeting SUMO to improve the efficiency of differentiation therapies in Acute Myeloid Leukemias

Acute Myeloid Leukemias (AML) are very aggressive hematological malignancies, which treatment is mostly based on intensive chemotherapies. This treatment has not significantly changed in the past 40 years and is characterized by a high relapse rate. Differentiation therapies, in particular those using all-trans retinoic acid (ATRA) are an alternative to chemotherapies. They aim at restoring the differentiation of AML cells … Continue reading Targeting SUMO to improve the efficiency of differentiation therapies in Acute Myeloid Leukemias

Tyrosine-1 of RNA Polymerase II CTD controls global termination of gene transcription in mammals.

Transcription of eukaryotic genomes requires an efficient termination to avoid pervasive transcript synthesis or interference. Here Shah, Maqbool et al show that tyrosine of RNA Polymerase II are essential for termination control and recruitment of Mediator and Integrator complexes. An unprecedently described massive read-through phenotype is observed when these residues are mutated.

Why low doses of anticancer drugs may be more effective ?

[ Article in French ]
Les équipes de Daniel Fisher à l’Institut de génétique moléculaire de Montpellier et de Michael Hochberg à l’Institut de sciences de l’évolution de Montpellier, apportent la première validation expérimentale du concept de la “Thérapie Adaptative” fondée sur les principes de l’évolution Darwinienne. Cette stratégie thérapeutique émergente repose sur l’idée, non encore validée, que l’administration de doses réduites d’anticancéreux qui arrêtent la prolifération des cellules cancéreuses, pourrait se révéler plus efficace en maintenant une compétition entre cellules sensibles et résistantes à la chimiothérapie.