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Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation

During thymic development and upon peripheral activation, T cells undergo extensive phenotypic and functional changes coordinated by lineage-specific developmental programs. To characterize the regulatory landscape controlling T cell identity, we performed a wide epigenomic and transcriptional analysis of mouse thymocytes and naive CD4 differentiated T helper cells. Our investigations reveal a dynamic putative enhancer landscape, and we could validate many … Continue reading Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation

Lamin C counteracts glucose intolerance in aging, obesity and diabetes through β-cell adaptation

Aging-dependent changes in tissue functions are associated with the development of metabolic diseases. However, the molecular connections linking aging, obesity and diabetes remain unclear. Alternative RNA processing of the Lmna gene produces distinct protein isoforms, lamin A, lamin C and progerin that have antagonistic functions on energy metabolism and lifespan. In a previous study, we showed that the lamin C … Continue reading Lamin C counteracts glucose intolerance in aging, obesity and diabetes through β-cell adaptation

Structural exploration of DNA folding helps to understand imprinting disorders.

In their study published in Genome Biology, David Llères and his co-workers (Genomic Imprinting and Development group headed by Robert Feil) explains how the structure of DNA controls the genes that are responsible for several of complex imprinting disorders. The genes that are involved in four of these human imprinting disorders (Beckwith-Wiedemann, Silver-Russell, Kagami-Ogata and Temple Syndromes) are organized in … Continue reading Structural exploration of DNA folding helps to understand imprinting disorders.

MitoTrack, a user-friendly semi-automatic software for lineage tracking in living embryos

During development, progenitor cells undergo multiple rounds of cellular divisions during which transcriptional programs must be faithfully propagated. To study mitotic inheritance of these programs, it is essential to be able to track transcriptional activities and their transmission from mother to daughter cells in living embryos. Given the stochastic nature of the phenomena, it is necessary to collect and analyze … Continue reading MitoTrack, a user-friendly semi-automatic software for lineage tracking in living embryos

Pierre Fabre Foundation : Laureate 2019

On May 20, 2019, the Pierre Fabre Foundation honored the 6 laureates of the Occitanie 2019 call project application, including Franck Mennechet’s project: Laboratory “Adenovirus: receptors, trafficking, immunogenicity & vectorology “ Location: IGMM, CNRS Project leader: Franck Mennechet (MCU University of Montpellier) Laboratory Director: Eric J Kremer (DR1 – INSERM) Océane Paris ( PhD) at the University of Montpellier – … Continue reading Pierre Fabre Foundation : Laureate 2019

Machine learning to probe transcription factor combinatorics

Transcription factors (TFs) act in a combinatorial manner competing and collaborating to regulate their target genes. Several questions remain regarding the conservation of these combinations among different gene classes, regulatory regions and cell types. Here we propose a new machine learning approach able to infer these combinations of TFs. This approach demonstrates that TF combinatorics are conserved for different gene … Continue reading Machine learning to probe transcription factor combinatorics