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MitoTrack, a user-friendly semi-automatic software for lineage tracking in living embryos

During development, progenitor cells undergo multiple rounds of cellular divisions during which transcriptional programs must be faithfully propagated. To study mitotic inheritance of these programs, it is essential to be able to track transcriptional activities and their transmission from mother to daughter cells in living embryos. Given the stochastic nature of the phenomena, it is necessary to collect and analyze … Continue reading MitoTrack, a user-friendly semi-automatic software for lineage tracking in living embryos

Pierre Fabre Foundation : Laureate 2019

On May 20, 2019, the Pierre Fabre Foundation honored the 6 laureates of the Occitanie 2019 call project application, including Franck Mennechet’s project: Laboratory “Adenovirus: receptors, trafficking, immunogenicity & vectorology “ Location: IGMM, CNRS Project leader: Franck Mennechet (MCU University of Montpellier) Laboratory Director: Eric J Kremer (DR1 – INSERM) Océane Paris ( PhD) at the University of Montpellier – … Continue reading Pierre Fabre Foundation : Laureate 2019

Machine learning to probe transcription factor combinatorics

Transcription factors (TFs) act in a combinatorial manner competing and collaborating to regulate their target genes. Several questions remain regarding the conservation of these combinations among different gene classes, regulatory regions and cell types. Here we propose a new machine learning approach able to infer these combinations of TFs. This approach demonstrates that TF combinatorics are conserved for different gene … Continue reading Machine learning to probe transcription factor combinatorics

Identification of a pathway regulating α-synuclein expression that could be used to develop new therapeutic strategies for Parkinson’s disease.

In this work, published in Cell Reports, Lassot et al. (« Molecular Mechanisms of Apoptosis Regulation»; Solange Desagher) describe a pathway regulating α-synuclein expression with in vivo and pathological relevance. Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. Although most cases of PD are sporadic, over 10% are associated with mutations in genes. SNCA, which encodes α-synuclein, … Continue reading Identification of a pathway regulating α-synuclein expression that could be used to develop new therapeutic strategies for Parkinson’s disease.

Two TRIM proteins control the degradation and the anti-apoptotic activity of BCL2A1 in melanoma cells.

Failure to eliminate cancer cells by apoptosis is crucial in tumor development. Therefore, the key approach to achieving successful antitumor response is to harness strategies allowing the elimination of pro-survival factors to the tumor. BCL2A1 is involved in chemoresistance of melanoma and is not targeted by BH3-mimetic inhibitors. In this study Lionnard et al reveal that TRIM28 and TRIM17 are … Continue reading Two TRIM proteins control the degradation and the anti-apoptotic activity of BCL2A1 in melanoma cells.

HRS-seq : a new genomic method reveals the importance of nuclear bodies in organizing the active chromosomal compartment

In a work published in Genome Research, Marie-Odile Baudement and its colleagues (team « Genome organization and epigenetic control » led by Thierry Forné), have developed the HRS-seq, a new straightforward genome-wide approach whereby they isolated and sequenced genomic regions associated with nuclear bodies and other membrane-less nuclear organelles which are made insoluble through high-salt treatments (HRS – High-salt Recovered … Continue reading HRS-seq : a new genomic method reveals the importance of nuclear bodies in organizing the active chromosomal compartment