News – Page 8

Structural exploration of DNA folding helps to understand imprinting disorders.

In their study published in Genome Biology, David Llères and his co-workers (Genomic Imprinting and Development group headed by Robert Feil) explains how the structure of DNA controls the genes that are responsible for several of complex imprinting disorders. The genes that are involved in four of these human imprinting disorders (Beckwith-Wiedemann, Silver-Russell, Kagami-Ogata and Temple Syndromes) are organized in … Continue reading Structural exploration of DNA folding helps to understand imprinting disorders.

MitoTrack, a user-friendly semi-automatic software for lineage tracking in living embryos

During development, progenitor cells undergo multiple rounds of cellular divisions during which transcriptional programs must be faithfully propagated. To study mitotic inheritance of these programs, it is essential to be able to track transcriptional activities and their transmission from mother to daughter cells in living embryos. Given the stochastic nature of the phenomena, it is necessary to collect and analyze … Continue reading MitoTrack, a user-friendly semi-automatic software for lineage tracking in living embryos

Meeting with the Occitanie / Languedoc-Roussillon Committee of the Foundation for Medical Research (FRM)

On October 14, 2019, the Occitanie / Languedoc-Roussillon Committee of the FRM invited donors and supporters to visit IGMM. On this event, the Director of the IGMM: Etienne Schwob and his research teams presented their work and projects funded by the FRM, particularly on the theme of leukaemias.

Modulation of T cell’s metabolism : towards a new therapeuthic approach against HIV infection

CD4 T cells are one of the main targets of HIV. The parameters that govern the biology of these cells and their susceptibility to the virus are of crucial importance in …

Pierre Fabre Foundation : Laureate 2019

On May 20, 2019, the Pierre Fabre Foundation honored the 6 laureates of the Occitanie 2019 call project application, including Franck Mennechet’s project: Laboratory “Adenovirus: receptors, trafficking, immunogenicity & vectorology “ Location: IGMM, CNRS Project leader: Franck Mennechet (MCU University of Montpellier) Laboratory Director: Eric J Kremer (DR1 – INSERM) Océane Paris ( PhD) at the University of Montpellier – … Continue reading Pierre Fabre Foundation : Laureate 2019

The laureates of the FRM Foundation

FRM LR Committee celebrated on 13 May 2019 at the Opera Comédie in Montpellier, the winners of national FRM foundation, with the presence of donors and many personalities. Of the fourteen winners, three from the IGMM: – Maelle Bellec (team M. Lagha) – Adham Safieddine (E. Bertrand team) – Eric Soler (E. Soler team)

Machine learning to probe transcription factor combinatorics

Transcription factors (TFs) act in a combinatorial manner competing and collaborating to regulate their target genes. Several questions remain regarding the conservation of these combinations among different gene classes, regulatory regions and cell types. Here we propose a new machine learning approach able to infer these combinations of TFs. This approach demonstrates that TF combinatorics are conserved for different gene … Continue reading Machine learning to probe transcription factor combinatorics

Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs

Pioneer transcription factors can engage nucleosomal DNA, which leads to local chromatin remodeling and to the establishment of transcriptional competence

Identification of a pathway regulating α-synuclein expression that could be used to develop new therapeutic strategies for Parkinson’s disease.

In this work, published in Cell Reports, Lassot et al. (« Molecular Mechanisms of Apoptosis Regulation»; Solange Desagher) describe a pathway regulating α-synuclein expression with in vivo and pathological relevance. Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. Although most cases of PD are sporadic, over 10% are associated with mutations in genes. SNCA, which encodes α-synuclein, … Continue reading Identification of a pathway regulating α-synuclein expression that could be used to develop new therapeutic strategies for Parkinson’s disease.

Two TRIM proteins control the degradation and the anti-apoptotic activity of BCL2A1 in melanoma cells.

Failure to eliminate cancer cells by apoptosis is crucial in tumor development. Therefore, the key approach to achieving successful antitumor response is to harness strategies allowing the elimination of pro-survival factors to the tumor. BCL2A1 is involved in chemoresistance of melanoma and is not targeted by BH3-mimetic inhibitors. In this study Lionnard et al reveal that TRIM28 and TRIM17 are … Continue reading Two TRIM proteins control the degradation and the anti-apoptotic activity of BCL2A1 in melanoma cells.