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Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production

Christelle Brégnard 1 , Jessica Guerra 1 , Stéphanie Déjardin 1 , Frank Passalacqua 1 , Monsef Benkirane 2 , Nadine Laguette 3

EBioMedicine . 2016 / pages 184-194.

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

J Guerra 1 , A-L Valadao 1 , D Vlachakis 2 , K Polak 1 , I K Vila 1 , C Taffoni 1 , T Prabakaran 3 , A S Marriott 4 , R Kaczmarek 5 , A Houel 6 , B Auzemery 1 , S Déjardin 1 , P Boudinot 6 , B Nawrot 5 , N J Jones 7 , S R Paludan 3 , S Kossida 8 , C Langevin 6 , N Laguette 1

Sci Adv . 2020 / pages 6(21):eaax3333

STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

Isabelle K Vila 1 , Hanane Chamma 2 , Alizée Steer 2 , Mathilde Saccas 2 , Clara Taffoni 2 , Evgenia Turtoi 3 , Line S Reinert 4 , Saqib Hussain 2 , Johanna Marines 5 , Lei Jin 6 , Xavier Bonnefont 7 , Mathieu Hubert 8 , Olivier Schwartz 8 , Soren R Paludan 4 , Gaetan Van Simaeys 9 , Gilles Doumont 10 , Bijan Sobhian 11 , Dimitrios Vlachakis 12 , Andrei Turtoi 3 , Nadine Laguette 13

Cell Metab . 2022 / pages 34(1):125-139.e8

DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma

Clara Taffoni # 1 , Johanna Marines # 1 2 , Hanane Chamma 1 , Soumyabrata Guha 1 , Mathilde Saccas 1 , Amel Bouzid 1 , Ana-Luiza Chaves Valadao 1 , Clément Maghe 3 4 , Jane Jardine 3 4 , Mi Kyung Park 5 , Katarzyna Polak 1 , Mara De Martino 6 , Claire Vanpouille-Box 6 , Maguy Del Rio 7 , Celine Gongora 7 , Julie Gavard 3 4 8 , Nicolas Bidère 3 4 , Min Sup Song 5 , Donovan Pineau 9 , Jean-Philippe Hugnot 9 , Karima Kissa 10 , Laura Fontenille 2 , Fabien P Blanchet 11 , Isabelle K Vila 1 , Nadine Laguette 1

EMBO J . 2023 / pages 42(7):e111961

The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling

Hanane Chamma, Soumyabrata Guha, Moritz Schüssler, Yasmine Messaoud-Nacer, Pierre Le Hars, Mohammad Salma, Joe McKellar, Joanna Re, Morgane Chemarin, Arnaud Carrier, Michael A. Disyak, Clara Taffoni, Robin Charpentier, Zoé Husson, Emmanuel Valjent, Charlotte Andrieu-Soler, Eric Soler, Karim Majzoub, Isabelle K. Vila, Nadine Laguette

bioRxiv 2025

The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA

Jesse Rabinowitz 1 , Isabelle K Vila 2 , Charlotte Luchsinger 1 , Cinzia Bertelli 1 , Moritz Schüssler 2 , Clara Taffoni 2 , Bin Cui 1 , Annie Zhi Dai 1 , Mohammad M Rashid 1 , William J Cisneros 3 , Daphne Cornish 3 , Juan Redondo 1 , Kathryn A Jackson-Jones 3 , Lacy M Simons 3 , Ramon Lorenzo-Redondo 3 , Nadine Laguette 2 , Judd F Hultquist 3 , Felipe Diaz-Griffero 4

J Biol Chem . 2025 / pages 301(8):110430

Targeting SUMOylation triggers interferon-ß-dependent activation of patient and allogenic Natural Killer cells in preclinical models of Acute Myeloid Leukemia

Rawan Hallal 1 , Marion de Toledo 2 , Denis Tempé 3 , Rayane Berrahouane 1 , Sara Zemiti 1 , Loïs Coënon 4 , Delphine Gitenay 5 , Simon George 1 , Moritz Schüssler 6 , Nadine Laguette 7 , Sarah Bonnet 8 , Ludovic Gabellier 8 , Guillaume Cartron 1 , Mireia Pelegrin 1 , Martin Villalba 9 , Guillaume Bossis 1

Mol Cancer Ther . 2025

Coordinated active repression operates via transcription factor cooperativity and multiple inactive promoter states in a developing organism

Virginia L Pimmett 1 , Maria Douaihy # 1 2 , Louise Maillard # 1 , Antonio Trullo 1 , Pablo Garcia Idieder 1 , Mélissa Costes 1 , Jeremy Dufourt 1 3 , Hélène Lenden-Hasse 1 , Ovidiu Radulescu 4 , Mounia Lagha 5

Nat Commun . / pages 16(1):8157

Synergistic DNA and RNA binding of the Hox transcription factor Ultrabithorax coordinates splicing and shapes in vivo homeotic functions

Constanza Blanco 1 , Wan Xiang 1 2 3 , Panagiotis Boumpas 1 4 , Elzéar Buvry 3 , Maily Scorcelletti 1 4 , Ashley Suraj Hermon 1 , Jiemin Wong 2 , Samir Merabet 1 , Julie Carnesecchi 3

Nucleic Acids Res . / pages 53(12):gkaf602.

The Kinase CK1α coordinates Initiation and Termination of the cGAS-STING Pathway

Jane Jardine, Marine Tarrillon, Gwennan André-Grégoire, Kilian Trillet, Vanessa Josso, Laura Merlet, Rosalie Moreau, Luc Antigny, François Guillonneau, Alice Boissard, Cécile Henry, Joanna Re, Sophie Barillé-Nion, Nadine Laguette, Philippe P. Juin, Julie Gavard, Nicolas Bidère

bioRxiv 2025

Spatio-temporal control of nuclear mechanotransduction during EMT

Ronan Bouzignac, Amandine Palandri, Amal Zine El Aabidine, Thomas Mangeat, Tatiana Merle, Martine Cazales, Antonio Trullo, Christian Rouviere, Virginia Pimmett, Mounia Lagha, Magali Suzanne

bioRxiv 2025

Synergistic DNA and RNA binding of the Hox transcription factor Ultrabithorax coordinates splicing and shapes in vivo homeotic functions

Constanza Blanco , Wan Xiang , Panagiotis Boumpas , Elzéar Buvry , Maily Scorcelletti , Ashley Suraj Hermon , Jiemin Wong , Samir Merabet , Julie Carnesecchi

Nucleic Acids Research 2025 / vol 53 12,8 / pages gkaf602

Explainable deep learning for stratified medicine in inflammatory bowel disease

Nora Verplaetse 1 , Piero Fariselli 2 , Yves Moreau 3 , Daniele Raimondi 3 4

Genome Biol . 2025 / pages 26(1):223

Imaging Translation in Early Embryo Development

Pierre Bensidoun 1 , Morgane Verbrugghe 1 , Mounia Lagha 2

Methods Mol Biol . 2025 / pages 2923:215-229

Genomic prediction with kinship-based multiple kernel learning produces hypothesis on the underlying inheritance mechanisms of phenotypic traits

Daniele Raimondi 1 2 , Nora Verplaetse 3 , Antoine Passemiers 3 , Deborah Sarah Jans 4 , Isabelle Cleynen 4 , Yves Moreau 3

Genome Biol . 2025 / pages 26(1):84

Reshaping transcription and translation dynamics during the awakening of the zygotic genome

Louise Maillard 1 , Pierre Bensidoun 1 , Mounia Lagha 2

Curr Opin Genet Dev. 2025 / pages 92:102344

Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription

Virginia L Pimmett 1 , James McGehee 2 , Antonio Trullo 1 , Maria Douaihy 1 3 , Ovidiu Radulescu 3 , Angelike Stathopoulos 2 , Mounia Lagha 1

Development 2025 / vol 2025 :dev204706. doi: 10.1242/dev.204706. Epub 2025 Mar 31. / pages 15;152(6)

Imaging Translation in Early Embryo Development

Pierre Bensidoun, Morgane Verbrugghe, Mounia Lagha

bioRxiv 2024

Regulation of bicoid mRNA throughout oogenesis and early embryogenesis impacts protein gradient formation

T. Athilingam, E.L. Wilby, P. Bensidoun, A. Trullo, M. Verbrugghe, M. Lagha, T.E. Saunders, T.T. Weil

bioRixiv 2024

Endogenous retroviral sequences behave as putative enhancers controlling gene expression through HP1-regulated long-range chromatin interactions

S. Calvet, S. Sallis, N. Saksouk, C. Rebouissou, C. Teyssier, A. Lesne, F. Cammas and T. Forné*

Cells 2022 / vol 11 / pages 2392

High-salt-recovered sequences are associated with the active chromosomal compartment and with large ribonucleoprotein complexes including nuclear bodies.

Baudement M-O., Cournac A., Court F., Seveno M., Parrinello H., Reynes C., Sabatier R., Bouschet T., Yi Z., Sallis S., Tancelin M., Rebouissou C., Cathala G., Lesne A., Mozziconacci* J., Journot* L. , Forné* T.

Genome Res 2018 / vol 28 / pages 1733-1746

Contribution of 3D genome topological domains to genetic risk of cancers: a genome-wide computational study

Kim Philipp Jablonski 1 2 , Leopold Carron 3 4 , Julien Mozziconacci 3 5 , Thierry Forné 6 , Marc-Thorsten Hütt 7 , Annick Lesne 8 9

Hum Genomics 2022 / pages 16(1):2

Organotypic culture of human brain explants as a preclinical model for AI-driven antiviral studies

Emma Partiot # 1 2 , Barbara Gorda # 1 2 , Willy Lutz 1 2 , Solène Lebrun 1 2 , Pierre Khalfi 2 3 , Stéphan Mora 2 3 , Benoit Charlot 2 4 , Karim Majzoub 2 3 , Solange Desagher 1 2 3 , Gowrishankar Ganesh 2 5 , Sophie Colomb 2 6 , Raphael Gaudin 7 8

EMBO Mol Med. / pages 16(4):1004-1026

Toll-like receptor 4 – a multifunctional virus recognition receptor.

Elina Gerber-Tichet 1 , Fabien P Blanchet 2 , Karim Majzoub 1 , Eric J Kremer 3

Trends Microbiol . / vol S0966-842X(24)00171-9.

Comparative analysis of human, rodent and snake deltavirus replication

Zoé Denis 1 , Pierre Khalfi 1 , Karim Majzoub 1

Med Sci (Paris) . ;. 2024 / pages 40(8-9):601-603

Boosting the toolbox for live imaging of translation

Maëlle Bellec 1 2 , Ruoyu Chen 3 4 , Jana Dhayni 5 , Antonello Trullo 1 , Damien Avinens 6 , Hussein Karaki 5 , Flavia Mazzarda 5 , Helene Lenden-Hasse 1 , Cyril Favard 6 , Ruth Lehmann 4 , Edouard Bertrand 7 , Mounia Lagha 1 , Jeremy Dufourt 8 6

RNA . 2024 / pages 30(10):1374-1394.

Direct observation of translational activation by a ribonucleoprotein granule

Ruoyu Chen 1 2 , William Stainier 1 3 , Jeremy Dufourt 4 5 , Mounia Lagha 4 , Ruth Lehmann 6 7

Nat Cell Biol. 2024 / pages 26(8):1322-1335

STING-ATF3/type I interferon crosstalk: A potential target to improve anti-tumour immunity in chemotherapy-treated urothelial carcinoma

Alexandra Fauvre 1 , Margot Machu 1 , Audrey Merienne 2 , Nadia Vie 1 , Thomas Bessede 1 , Mathilde Robin 1 , Veronique Garambois 1 , Clara Taffoni 3 , Nadine Laguette 3 , Nadine Gervois-Segain 2 , Anne Jarry 2 , Nathalie Labarriere 2 , Yves Allory 4 , Christel Larbouret 1 , Laurent Gros 1 , Diego Tosi 1 , David B Solit 5 , Philippe Pourquier 1 , Nadine Houédé 1 , Celine Gongora 1

Clin Transl Med . 2024 / pages 14(9):e70011.

DNA-PK controls cyclic dinucleotide-associated type I Interferon responses

Clara Taffoni, Isabelle K. Vila, Jane Jardine, Moritz Schussler, Joe McKellar, Morgane Chemarin, Joanna Re, Yasmine Messaout-Nacer, Insaf El Mansouri, George P Chrousos, Nicolas Bidère, Karim Majzoub, Dimitrios Vlachakis, View Nadine Laguette

bioRxiv 2024

To Ubiquitinate or Not to Ubiquitinate: TRIM17 in Cell Life and Death

Meenakshi Basu-Shrivastava 1 , Alina Kozoriz 1 , Solange Desagher 1 , Iréna Lassot 1

Cells 2021 / pages 10(5):1235

DeSUMOylation of chromatin-bound proteins limits the rapid transcriptional reprogramming induced by daunorubicin in acute myeloid leukemias

Mathias Boulanger 1 , Mays Aqrouq 1 , Denis Tempé 1 , Chamseddine Kifagi 1 , Marko Ristic 1 , Dana Akl 1 , Rawan Hallal 1 , Aude Carusi 1 , Ludovic Gabellier 1 2 , Marion de Toledo 1 , Jon-Otti Sigurdsson 3 , Tony Kaoma 4 , Charlotte Andrieu-Soler 1 5 , Thierry Forné 1 , Eric Soler 1 5 , Yosr Hicheri 2 , Elise Gueret 6 , Laurent Vallar 4 , Jesper V Olsen 3 , Guillaume Cartron 1 2 , Marc Piechaczyk 1 , Guillaume Bossis 1

Nucleic Acids Res . 2023 / pages 51(16):8413-8433

Chromatin and DNA Dynamics in Mouse Models of Liver Cancers

Julie Sanceau 1 2 , Thierry Forné 3 , Sophie Chantalat 4 , Angélique Gougelet 5 6

Methods Mol Biol. 2024 / pages 2769:167-187

DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis

Julie Sanceau 1 , Lucie Poupel 2 , Camille Joubel 1 , Isabelle Lagoutte 3 , Stefano Caruso 4 , Sandra Pinto 5 , Christèle Desbois-Mouthon 1 , Cécile Godard 1 , Akila Hamimi 1 , Enzo Montmory 1 , Cécile Dulary 6 , Sophie Chantalat 6 , Amélie Roehrig 4 , Kevin Muret 6 , Benjamin Saint-Pierre 3 , Jean-François Deleuze 6 , Sophie Mouillet-Richard 4 , Thierry Forné 7 , Christophe F Grosset 8 , Jessica Zucman-Rossi 4 , Sabine Colnot 1 , Angélique Gougelet 9

Mol Ther . 2024 / pages 32(4):1125-1143

Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma

Anthony Lozano 1 , Francois-Régis Souche 1 2 , Carine Chavey 1 , Valérie Dardalhon 1 , Christel Ramirez 3 , Serena Vegna 3 , Guillaume Desandre 1 , Anaïs Riviere 1 , Amal Zine El Aabidine 1 , Philippe Fort 4 , Leila Akkari 3 , Urszula Hibner # 1 , Damien Grégoire # 1

Elife 2023 / pages 12:e76294

FGF19 and its analog Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis

José Ursic-Bedoya # 1 2 , Guillaume Desandré # 1 , Carine Chavey 1 , Pauline Marie 1 , Arnaud Polizzi 3 , Benjamin Rivière 4 , Hervé Guillou 3 , Eric Assenat 1 2 , Urszula Hibner 1 , Damien Gregoire 5

EMBO Mol Med . 2024 Feb;16(2):238-250. 2024 / pages 16(2):238-250.

The long non-coding RNA Meg3 mediates imprinted gene expression during stem cell differentiation

Sabina Farhadova 1 2 3 , Amani Ghousein 1 2 , François Charon 4 , Caroline Surcis 1 , Melisa Gomez-Velazques 1 2 , Clara Roidor 1 2 , Flavio Di Michele 1 2 , Maud Borensztein 1 2 , Albertina De Sario 2 5 , Cyril Esnault 1 2 , Daan Noordermeer 4 , Benoit Moindrot 4 , Robert Feil 1 2

Nucleic Acids Res . 2024 Apr 13:gkae247. 2024

Comparative analysis of human, rodent and snake deltavirus replication

Pierre Khalfi 1 , Zoé Denis 1 , Joe McKellar 1 , Giovanni Merolla 1 , Carine Chavey 1 , José Ursic-Bedoya 1 2 , Lena Soppa 3 , Leonora Szirovicza 4 , Udo Hetzel 5 , Jeremy Dufourt 1 6 , Cedric Leyrat 7 , Nora Goldmann 3 , Kaku Goto 8 9 , Eloi Verrier 8 9 , Thomas F Baumert 8 9 , Dieter Glebe 3 , Valérie Courgnaud 1 , Damien Gregoire 1 , Jussi Hepojoki 4 5 , Karim Majzoub 1

PLoS Pathog . 2024 / pages 20(3):e1012060.

Dissecting the dynamics of coordinated active transcriptional repression in a multicellular organism

Virginia Pimmett, Maria Douaihy, Louise Maillard, Antonio Trullo, Ovidiu Radulescu, Mounia Lagha

Biorxiv 2024

Transcription: A hub of activity

Virginia L Pimmett, Mounia Lagha

eLife

Broadening our view on nucleic acid sensing: novel sensors, signaling pathways, and involvement in non-infectious diseases

Lise Chauveau 1 , Nadine Laguette 2 , Natalia G Sampaio 3 4

Front Immunol . 2023 / pages 14:1266732