The possibility to arrest transcription elongation by bis-PNA has been investigated. No arrest of transcription has been obtained in intact cells at variance with the data observed with purified RNA-polymerases. In keeping with these data a purified DNA-helicase (UL9) cannot be fully inhibited by such complexes.
Inhibition of DNA transcription elongation and unwinding by bis-PNA
Bastide, L.; Villani, G.; Nielsen, P.; Boehmer, P. E.; Lebleu, B.
Nucleosides & Nucleotides
1999 / vol 18 / pages 1669-1671
helicase; strand; triple-helix