Publications

Transcription: A hub of activity

Virginia L Pimmett, Mounia Lagha

eLife

Broadening our view on nucleic acid sensing: novel sensors, signaling pathways, and involvement in non-infectious diseases

Lise Chauveau 1 , Nadine Laguette 2 , Natalia G Sampaio 3 4

Front Immunol . 2023 / pages 14:1266732

Multiplexed targeted analysis of polyunsaturated fatty acids and oxylipins using liquid chromatography-tandem mass spectrometry

Evgenia Turtoi 1 , Jeremy Jeudy 2 , Gilles Valette 3 , Christine Enjalbal 3 , Isabelle K Vila 4 , Nadine Laguette 4 , Andrei Turtoi 5

STAR Protoc. 2023 / pages 4(3):102226

Towards a novel approach to stimulate anti-tumoral immunity in glioblastoma

Clara Taffoni 1 , Nadine Laguette 1

Med Sci (Paris) 2023 / pages 39(11):813-815

Mechanisms of eukaryotic transcription termination at a glance

Juanjuan Xie 1 , Domenico Libri 2 , Odil Porrua 2

J Cell Sci . / pages 136(1):jcs259873

Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor

Zdenka Hasanova 1 , Veronika Klapstova 1 2 , Odil Porrua 3 4 , Richard Stefl 1 2 , Marek Sebesta 1

Nucleic Acids Res . 2023 / pages 51(6):2818-2837

Senataxin: A key actor in RNA metabolism, genome integrity and neurodegeneration

Marta Giannini 1 , Odil Porrua 2

Biochimie 2023 Aug 7 / pages S0300-9084(23)00184-0

A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation

Juan Manuel Valverde # 1 2 , Geronimo Dubra # 3 4 , Michael Phillips 5 , Austin Haider 6 , Carlos Elena-Real 7 , Aurélie Fournet 7 , Emile Alghoul 8 , Dhanvantri Chahar 3 4 , Nuria Andrés-Sanchez 3 4 , Matteo Paloni 5 , Pau Bernadó 7 , Guido van Mierlo 9 , Michiel Vermeulen 9 , Henk van den Toorn 1 2 , Albert J R Heck 1 2 , Angelos Constantinou 8 , Alessandro Barducci 7 , Kingshuk Ghosh 5 6 , Nathalie Sibille 7 , Puck Knipscheer 10 , Liliana Krasinska 3 4 , Daniel Fisher 11 12 , Maarten Altelaar 13 14

Nat Commun 2023 / pages 14(1):6316

Boosting the toolbox for live imaging of translation

Maelle Bellec, Ruoyu Chen, Jana Dhayni, Cyril Favard, Antonello Trullo, Helene Lenden-Hasse, Ruth Lehmann, Edouard Bertrand, Mounia Lagha, Jeremy Dufourt

BioRxiv 2023

BurstDECONV: a signal deconvolution method to uncover mechanisms of transcriptional bursting in live cells

Maria Douaihy 1 2 , Rachel Topno 1 3 , Mounia Lagha 2 , Edouard Bertrand 3 , Ovidiu Radulescu 1

Nucleic Acids Res . 2023 / pages 51(16):e88

Repressor sequestration activates translation of germ granule localized mRNA

Ruoyu Chen, William Stainier, Jeremy Dufourt, Mounia Lagha, Ruth Lehmann

BioRxiv 2023

Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair

Nikolaos Parisis 1 2 3 4 , Pablo D Dans 5 6 7 , Muhammad Jbara 8 9 , Balveer Singh 10 , Diane Schausi-Tiffoche 10 , Diego Molina-Serrano 10 , Isabelle Brun-Heath 5 , Denisa Hendrychová 1 2 11 , Suman Kumar Maity 8 , Diana Buitrago 5 , Rafael Lema 5 , Thiziri Nait Achour 1 2 , Simona Giunta 12 13 , Michael Girardot 1 , Nicolas Talarek 1 , Valérie Rofidal 3 , Katerina Danezi 1 2 , Damien Coudreuse 10 14 , Marie-Noëlle Prioleau 4 , Robert Feil 1 , Modesto Orozco 5 , Ashraf Brik 8 , Pei-Yun Jenny Wu 10 14 , Liliana Krasinska 15 16 , Daniel Fisher 17 18

Nat Commun . ; 2023 / pages 14(1):5104

Efficient genome editing in erythroid cells unveils novel MYB target genes and regulatory functions

Virginie Deleuze 1 , Leonor Garcia 1 , Betty Rouaisnel 1 , Mohammad Salma 1 2 , Alexia Kinoo 1 , Charlotte Andrieu-Soler 1 2 , Eric Soler 1 2

iScience / pages 26(9):107641

Imprinted Long Non-Coding RNAs in Mammalian Development and Disease

Flavio Di Michele 1 2 , Isabel Chillón 1 2 , Robert Feil 1 2

Int J Mol Sci . 2023 / pages 24(17):13647

Viral vector-mediated expression of NaV1.1, after seizure onset, reduces epilepsy in mice with Dravet syndrome

Saja Fadila 1 2 , Bertrand Beucher 3 4 , Iria González Dopeso-Reyes 3 , Anat Mavashov 5 , Marina Brusel 1 , Karen Anderson 1 , Caroline Ismeurt 3 , Ethan M Goldberg 6 7 , Ana Ricobaraza 8 , Ruben Hernandez-Alcoceba 8 , Eric J Kremer 3 , Moran Rubinstein 1 2 5

J Clin Invest . 2023 / pages 133(12):e159316

DeSUMOylation of chromatin-bound proteins limits the rapid transcriptional reprogramming induced by daunorubicin in acute myeloid leukemias

Mathias Boulanger 1 , Mays Aqrouq 1 , Denis Tempé 1 , Chamseddine Kifagi 1 , Marko Ristic 1 , Dana Akl 1 , Rawan Hallal 1 , Aude Carusi 1 , Ludovic Gabellier 1 2 , Marion de Toledo 1 , Jon-Otti Sigurdsson 3 , Tony Kaoma 4 , Charlotte Andrieu-Soler 1 5 , Thierry Forné 1 , Eric Soler 1 5 , Yosr Hicheri 2 , Elise Gueret 6 , Laurent Vallar 4 , Jesper V Olsen 3 , Guillaume Cartron 1 2 , Marc Piechaczyk 1 , Guillaume Bossis 1

Nucleic Acids Res . 2023 / pages 51(16):8413-8433

SUMOylation inhibitor TAK-981 (subasumstat) synergizes with 5-azacitidine in preclinical models of acute myeloid leukemia

Ludovic Gabellier 1 , Marion De Toledo 2 , Mehuli Chakraborty 3 , Dana Akl 3 , Rawan Hallal 3 , Mays Aqrouq 3 , Giovanni Buonocore 3 , Clara Recasens-Zorzo 3 , Guillaume Cartron 1 , Abigaïl Delort 4 , Marc Piechaczyk 3 , Denis Tempé 5 , Guillaume Bossis 6

Haematologica 2023

Evidence for low nanocompaction of heterochromatin in living embryonic stem cells

Claire Dupont 1 , Dhanvantri Chahar 1 , Antonio Trullo 1 , Thierry Gostan 1 , Caroline Surcis 1 , Charlotte Grimaud 2 , Daniel Fisher 1 , Robert Feil 1 , David Llères 1

EMBO J . 2023 / pages 42(12):e110286

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium

Susana Prieto 1 2 , Geronimo Dubra 1 2 , Alain Camasses 1 2 , Ana Bella Aznar 1 2 , Christina Begon-Pescia 1 , Elisabeth Simboeck 1 2 , Nelly Pirot 3 4 , François Gerbe 2 5 , Lucie Angevin 1 2 , Philippe Jay 2 5 , Liliana Krasinska 1 2 , Daniel Fisher 1 2

EMBO Rep . 2023 / pages 24(2):e54261

RNA polymerase II CTD is dispensable for transcription and required for termination in human cells

Yousra Yahia # 1 , Alexia Pigeot # 1 , Amal Zine El Aabidine # 1 , Nilay Shah 2 , Nezih Karasu 1 3 , Ignasi Forné 4 , Stefan Krebs 5 , Helmut Blum 5 , Cyril Esnault 1 , Tom Sexton 3 , Axel Imhof 4 , Dirk Eick 2 , Jean-Christophe Andrau 1

EMBO Rep. 2023

Multiple Fra-1-bound enhancers showing different molecular and functional features can cooperate to repress gene transcription

Bejjani, F., Evanno, E., Mahfoud, S., Tolza, C., Zibara, K., Piechaczyk, M. and Jariel-Encontre, I.

Cell & Bioscience 2023

G4access identifies G-quadruplexes and their associations with open chromatin and imprinting control regions

Cyril Esnault # 1 , Talha Magat # 1 , Amal Zine El Aabidine # 1 , Encar Garcia-Oliver # 1 , Anne Cucchiarini 2 , Soumya Bouchouika 1 , David Lleres 1 , Lutz Goerke 1 , Yu Luo 2 3 , Daniela Verga 3 , Laurent Lacroix 4 , Robert Feil 1 , Salvatore Spicuglia 5 6 , Jean-Louis Mergny 2 , Jean-Christophe Andrau 7

Nat Genet . 2023

Harnessing the cooperation between DNA-PK and cGAS in cancer therapies: The cooperation between DNA-PK and cGAS shapes tumour immunogenicity

Clara Taffoni 1 , Moritz Schüssler 1 , Isabelle K Vila 1 , Nadine Laguette 1

Bioessays . 2023 / pages e2300045.

The unexpected role of the STING protein in lipid metabolism

Isabelle K Vila, Nadine Laguette

C R Biol . 2023 / vol 346 / pages 29-33

Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions

Dylan J Harney 1 , Michelle Cielesh 2 , Georgia E Roberts 1 , Isabelle K Vila 3 , Barney Viengkhou 1 , Markus J Hofer 1 , Nadine Laguette 3 , Mark Larance 4

Cell Rep. 2023 / vol 42(6) / pages 112559

Inhibition of noradrenergic signalling in rodent orbitofrontal cortex impairs the updating of goal-directed actions

Juan Carlos Cerpa # 1 , Alessandro Piccin # 1 , Margot Dehove 1 , Marina Lavigne 2 , Eric J Kremer 2 , Mathieu Wolff 1 , Shauna L Parkes 1 , Etienne Coutureau 1

Elife 2023 / vol 12 / pages e81623

RNA transport from transcription to localized translation: a single molecule perspective

Eugenia Basyuk 1 2 , Florence Rage 3 , Edouard Bertrand 1 3 4

RNA Biol . 2021 / vol 18(9) / pages 1221-1237

Evidence for low nanocompaction of heterochromatin in living embryonic stem cells

Claire Dupont 1 , Dhanvantri Chahar 1 , Antonio Trullo 1 , Thierry Gostan 1 , Caroline Surcis 1 , Charlotte Grimaud 2 , Daniel Fisher 1 , Robert Feil 1 , David Llères 1

EMBO J . 2023 Apr 21;e110286. 2023

Probing instructions for expression regulation in gene nucleotide compositions

Chloé Bessière 1 2 , May Taha 1 2 3 , Florent Petitprez 1 2 , Jimmy Vandel 1 4 , Jean-Michel Marin 1 3 , Laurent Bréhélin 1 4 , Sophie Lèbre 1 3 5 , Charles-Henri Lecellier 1 2

PLoS Comput Biol . 2018 / vol 14(1) / pages e1005921

Human Enhancers Harboring Specific Sequence Composition, Activity, and Genome Organization Are Linked to the Immune Response

Charles-Henri Lecellier 1 2 3 , Wyeth W Wasserman 3 , Anthony Mathelier 4 5 6

Genetics . 2018 Aug;:. doi: 10.1534/genetics.118.301116. Epub 2018 Jun 5. 2018 / vol 209(4) / pages 1055-1071

Probing transcription factor combinatorics in different promoter classes and in enhancers

Jimmy Vandel 1 2 , Océane Cassan 1 2 , Sophie Lèbre 2 3 4 , Charles-Henri Lecellier 5 6 , Laurent Bréhélin 7 8 Jimmy Vandel 1 2 , Océane Cassan 1 2 , Sophie Lèbre 2 3 4 , Charles-Henri Lecellier 5 6 , Laurent Bréhélin 7 8

BMC Genomics . 2019 / vol 20(1) / pages 103

Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers

Fabienne Bejjani 1 2 , Claire Tolza 1 , Mathias Boulanger 1 , Damien Downes 3 , Raphaël Romero 4 5 , Muhammad Ahmad Maqbool 1 , Amal Zine El Aabidine 1 , Jean-Christophe Andrau 1 , Sophie Lebre 4 , Laurent Brehelin 5 , Hughes Parrinello 6 , Marine Rohmer 6 , Tony Kaoma 7 , Laurent Vallar 8 , Jim R Hughes 3 , Kazem Zibara 2 9 , Charles-Henri Lecellier 1 5 , Marc Piechaczyk 1 , Isabelle Jariel-Encontre 1

Nucleic Acids Res . 2021 / vol 49(5) / pages 2488-2508

Identification of long regulatory elements in the genome of Plasmodium falciparum and other eukaryotes

Christophe Menichelli 1 , Vincent Guitard 2 , Rafael M Martins 2 , Sophie Lèbre 3 4 , Jose-Juan Lopez-Rubio 2 , Charles-Henri Lecellier 1 5 , Laurent Bréhélin 1

PLoS Comput Biol. 2021 / vol 17(4) / pages e1008909

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mathys Grapotte # 1 2 3 , Manu Saraswat # 1 2 , Chloé Bessière # 1 2 , Christophe Menichelli 1 4 , Jordan A Ramilowski 5 , Jessica Severin 5 , Yoshihide Hayashizaki 6 , Masayoshi Itoh 6 , Michihira Tagami 5 , Mitsuyoshi Murata 5 , Miki Kojima-Ishiyama 5 , Shohei Noma 5 , Shuhei Noguchi 5 , Takeya Kasukawa 5 , Akira Hasegawa 5 , Harukazu Suzuki 5 , Hiromi Nishiyori-Sueki 5 , Martin C Frith 7 8 9 ; FANTOM consortium; Clément Chatelain 3 , Piero Carninci 5 , Michiel J L de Hoon 5 , Wyeth W Wasserman 10 , Laurent Bréhélin 11 12 , Charles-Henri Lecellier 13 14 15

Nat Commun 2021 / vol 12(1) / pages 3297

HT-smFISH: a cost-effective and flexible workflow for high-throughput single-molecule RNA imaging

Adham Safieddine 1 2 , Emeline Coleno 3 4 , Frederic Lionneton 5 , Abdel-Meneem Traboulsi 3 , Soha Salloum 3 4 , Charles-Henri Lecellier 3 6 , Thierry Gostan 3 , Virginie Georget 5 , Cédric Hassen-Khodja 5 , Arthur Imbert 7 8 9 , Florian Mueller 10 , Thomas Walter 7 8 9 , Marion Peter 3 11 , Edouard Bertrand 12 13 14

Nat Protoc . 2023 / vol 18(1) / pages 157-187

Short tandem repeats are important contributors to silencer elements in T cells

Hepatitis D virus: Improving virological knowledge to develop new treatments

Pierre Khalfi 1 , Patrick T Kennedy 2 , Karim Majzoub 3 , Tarik Asselah 4

Antiviral Res . 2023 / vol 209 / pages 105461

A Microbead-Based Flow Cytometry Assay to Assess the Activity of Ubiquitin and Ubiquitin-Like Conjugating Enzymes

Clara Recasens-Zorzo 1 2 , Pierre Gâtel 1 2 , Frédérique Brockly 1 2 , Guillaume Bossis 3 4

Methods Mol Biol. 2023 / vol 2602 / pages 65-79

Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice

Damien Dufour 1 , Typhanie Dumontet 1 2 3 , Isabelle Sahut-Barnola 1 , Aude Carusi 4 , Méline Onzon 1 , Eric Pussard 5 , James Jr Wilmouth 1 , Julie Olabe 1 , Cécily Lucas 1 6 , Adrien Levasseur 1 , Christelle Damon-Soubeyrand 1 , Jean-Christophe Pointud 1 , Florence Roucher-Boulez 1 6 , Igor Tauveron 1 7 , Guillaume Bossis 4 , Edward T Yeh 8 , David T Breault 9 10 , Pierre Val 1 , Anne-Marie Lefrançois-Martinez 1 , Antoine Martinez 11

Nat Commun 2022 / vol 13(1) / pages 7858

Mutations in the non-coding RNU4ATAC gene affect the homeostasis and function of the Integrator complex

Fatimat Almentina Ramos Shidi 1 , Audric Cologne 2 , Marion Delous 3 , Alicia Besson 3 , Audrey Putoux 3 4 , Anne-Louise Leutenegger 5 , Vincent Lacroix 2 , Patrick Edery 3 4 , Sylvie Mazoyer 3 , Rémy Bordonné 1

Nucleic Acids Res . 2022