The thymus forms as an alymphoid thymic primordium with T cell differentiation requiring the seeding of this anlage. This review will focus on the characteristics of the hematopoietic progenitors which colonize the thymus and their subsequent commitment/differentiation, both in mice and men. Within the thymus, the interplay between Notch1 and IL-7 signals is crucial for the orchestration of T cell development, but the precise requirements for these factors in murine and human thympoeisis are not synonymous. Recent advances in our understanding of the mechanisms regulating precursor entry and their maintenance in the thymus will also be presented.
Molecular and cellular basis of T cell lineage commitment
Vicente, R.; Swainson, L.; Marty-Gres, S.; De Barros, S. C.; Kinet, S.; Zimmermann, V. S.; Taylor, N.
2010-10 / vol 22 / pages 270-5
S1044-5323(10)00057-6 [pii] 10.1016/j.smim.2010.04.016
1096-3618 (Electronic) 1044-5323 (Linking)
IGMM team(s) involved in this publication
NAOMI TAYLOR / Valerie Zimmermann
Hematopoiesis and Immunotherapy
Humans; Animals; Cell Differentiation; Interleukin-7/immunology/metabolism; *Cell Lineage; Receptor, Notch1/immunology/metabolism; T-Lymphocytes/*cytology/*immunology